摘要
目的观察神经节苷脂对急性脑出血患者的疗效及其对肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)及C反应蛋白(CRP)的影响。方法选择2014年3月至2016年3月我院收治的118例急性脑出血患者作为研究对象。以数字法将其分为观察组及对照组,每组59例。观察组患者给予神经节苷脂进行治疗,对照组患者给予胞磷胆碱钠进行治疗,观察两组的疗效及TNF-α、IL-1β、CRP的变化。结果观察组疗效优者占61.02%(36/59),优良率为98.31%(58/59),明显高于对照组的35.59%(21/59)及76.27%(45/59)(P<0.05)。观察组呕吐、头痛以及食欲不振的患者数量均明显少于对照组(P<0.05)。治疗后观察组与对照组的评分均得到明显改善(P<0.05),但观察组的降低程度明显优于对照组(P<0.05)。观察组与对照组的TNF-α、IL-1β及CRP水平在治疗后均明显降低(P<0.05),但观察组的降低程度明显高于对照组(P<0.05)。结论神经节苷脂能够有效调节急性脑出血患者的TNF-α、IL-1β及CRP水平,并且能改善患者生活质量,缓解疼痛,效果较好。
Objective To study the efficacy of ganglioside on patients with acute cerebral hemorrhage and its effect on TNF-α,IL-1β and CRP.Methods Totally 118 cases of acute cerebral hemorrhage from March 2014 to March 2016 in our hospital were selected,and divided into observation group and control group by digital method.Each group had 59 cases.Observation group was treated with ganglioside,and control group was treated with citicoline sodium.The efficacy of treatment and the effect on TNF-α,IL-1β and CRP in two groups were compared.Results After the different treatments,the good treatment rate in observation group was 61.02%（36/59）,and the excellent rate was98.31%（58/59）,which were significantly higher than those of control group（35.59%,21/59;76.27%,45/59.P〈0.05）.The incidence of vomiting,headache and loss of appetite in observation group was significantly less than those of control group（P 〈0.05）.The scores were obviously adjusted after treatment in both groups（P〈 0.05）.The score of observation group decreased more significantly than that of control group（P 〈0.05）.The level of TNF-α,IL-1β and CRP were effectively reduced after treatment in both groups（P 〈0.05）.The above indexes of observation group decreased more significantly than those of control group（P 〈0.05）.Conclusion Ganglioside can effectively regulate the level of TNF-α,IL-1β and CRP in patients with acute cerebral hemorrhage patients,and improve the quality of life of patients with pain relief,which has better effects.
出处
《实用药物与临床》
CAS
2017年第2期189-191,共3页
Practical Pharmacy and Clinical Remedies
