摘要
【目的】研究藏药雪莲联合糖皮质激素在放射性肺炎进展期的干预作用。【方法】选取65例接受食道癌放疗后的放射性肺炎患者,随机分为3组:西药组20例、联合组21例和藏药组24例。西药组给予口服泼尼松(剂量为1 mg/kg)治疗,联合组给予口服泼尼松(剂量为0.5 mg/kg)联合肌肉注射雪莲注射液(剂量为2 m L/d)治疗,藏药组给予肌肉注射雪莲注射液(剂量为4 m L/d)治疗,以上药物均持续应用6周。观察各组患者治疗前后胸部高分辨率CT(HRCT)评分、LCQ咳嗽评分、6 min步行试验、肺功能[肺活量(VC),肺总量(TLC),弥散功能(DLco)]、动脉血气分析[动脉氧分压(PO2)]等的变化情况。【结果】(1)治疗后,联合组HRCT评分、6 min步行试验、LCQ咳嗽评分的改善值均高于西药组和藏药组(P<0.05),而藏药组仅LCQ咳嗽评分中的心理、社会评分改善值及改善后总分高于西药组(P<0.05)。(2)治疗后,联合组及藏药组的肺功能及PO2改善值均高于西药组(P<0.05),且联合组肺功能中的DLco及PO2改善值也均高于藏药组(P<0.05)。【结论】雪莲注射液联合糖皮质激素对于进展期的放射性肺炎有较好的治疗作用;大剂量雪莲注射液对于进展期的放射性肺炎的症状及影像学改善也有一定的帮助。
Objective To study the therapeutic effect of Tibetan medicine Flos Saussureae combined with glucocorticoid for progressive stage of radiation pneumonia. Methods A total of 65 post-chemotherapy radiation pneumonia patients with esophageal carcinoma were randomized into western medicine group（20 cases）,combined group（21 cases）and Flos Saussureae group（24 cases）,which were treated with prednisone（1 mg/kg,orally）,prednisone（0.5 mg/kg,orally）plus Flos Saussureae Injection（2 m L/d, by intramuscular injection）,and Flos Saussureae Injection（4 m L/d,by intramuscular injection）respectively. The medication lasted for 6 weeks. Before and after treatment,we investigated the scores of chest high resolution CT（HRCT）,Leicester Cough Questionnaire（LCQ）scores,6-minute walk distance,pulmonary function indexes of vital capacity（VC）,total lung capacity（TLC）and diffusion function DLco,and arterial oxygen partial pressure（PO2）. Results（1）The scores of HRCT,6-minute walk distance and LCQ scores of the combined group were improved as compared with those of western medicine group and Flos Saussureae group（P〈0.05）. The improvement of psychological scores, social function scores and overall socres of LCQ in Flos Saussureae group was superior to that in western medicine group（P〈0.05）.（2）After treatment, pulmonary function indexes and PO2 of the combined group and Flos Saussureae group were improved compared with those of western medicine group（P〈0.05）,and the improvement of DLco and PO2 of the combined group was superior to that of Flos Saussureae group（P〈0.05）. Conclusion Flos Saussureae Injection combined with glucocorticoid exerts certain therapeutic effect for progressive stage of radiation pneumonia, and large-dose Flos Saussureae Injection is beneficial to the improvement of symptoms and imaging features of the patients.
出处
《广州中医药大学学报》
CAS
2017年第2期185-188,共4页
Journal of Guangzhou University of Traditional Chinese Medicine
关键词
食道癌放疗后
放射性肺炎
进展期
雪莲注射液
泼尼松
post-chemotherapy for esophageal carcinoma
radiation pneumonia
progressive stage
Flos Saussureae Injection
glucocorticoid
