摘要
目的探讨尼莫地平对急性脑出血血清超敏C-反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、高迁移率蛋白-1(HMGB-1)的变化及效果影响。方法将2013年7月—2015年7月收治急性脑出血84例依治疗方法不同分为对照组和观察组,每组42例。对照组行常规治疗,观察组在常规治疗基础上联合尼莫地平治疗,治疗4周后,观察两组临床效果及不良反应,比较治疗前后血清hs-CRP、IL-6、HMGB-1及脑水肿体积、脑血肿体积、神经功能缺损(NDS)评分的变化。结果治疗前血清hs-CRP、IL-6、HMGB-1水平比较差异无统计学意义(P>0.05),治疗后均低于治疗前(P<0.01);治疗后观察组血清hs-CRP、IL-6、HMGB-1水平均低于对照组(P<0.01)。两组治疗前脑水肿体积、脑血肿体积、NDS评分比较差异无统计学意义(P>0.05),治疗后均低于治疗前(P<0.01);治疗后观察组脑水肿体积、脑血肿体积、NDS评分均低于对照组(P<0.01)。观察组治疗有效率明显高于对照组(P<0.05)。两组不良反应比较差异无统计学意义(P>0.05)。结论应用尼莫地平治疗急性脑出血效果确切,安全性高,可有效降低血清hs-CRP、IL-6、HMGB-1水平,减轻炎症反应,缓解脑部血流,保护神经功能,改善预后。
Objective To investigate changes and effect of Nimodipine on serum high sensitive c-reactive protein（ hs-CRP）,interleukin-6（ IL-6） and high mobility protein-1 in treatment of acute cerebral hemorrhage. Methods A total of 84 patients with acute cerebral hemorrhage admitted during July 2013 and July 2015 were divided into control group（ n = 42） and observation group（ n = 42） according to different treatment methods. Control group received routine treatment,while observation group was treated with Nimodipine on the basis of routine treatment. After treatment for four weeks,efficacy and adverse reactions were observed,and changes of the indexes including serum hs-CRP,IL-6,high mobility protein-1,volume of cerebral edema,volume of brain edema and neurological deficit score（ NDS） were compared before and after treatment in two groups. Results Before treatment,there were no significantly differences in hsCRP,IL-6 and high mobility protein-1 between two groups（ P〉0. 05）; the levels of above indexes were significantly lower after treatment than those before treatment（ P〈0. 01）. After treatment,levels of hs-CRP,IL-6 and high mobility protein-1 in observation group were significantly lower than those in control group（ P〈0. 01）. Before treatment,there were no significant differences in volume of cerebral edema,volume of brain edema and NDS（ P〈0. 05）; the levels of above indexes were significantly lower after treatment than those before treatment（ P〈0. 01）. After treatment,values of volume of cerebral edema,volume of brain edema and neurologic impairment score in observation group were significantly lower than those in control group（ P〈0. 05）. Effective rate in observation group was significantly higher than that in control group（ P〈0. 01）. There was no significant difference in incidence rate of adverse reactions between two groups（ P〉0. 05）. Conclusion Nimodipine in treatment of patients with acute cerebral hemorrhage is effective and safe. Moreover,it can
出处
《解放军医药杂志》
CAS
2017年第2期91-94,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
