摘要
目的研究脑梗死(CI)及多梗死性痴呆(MID)患者血清高迁移率蛋白-1(HMGB1)、神经元特异性烯醇化酶(NSE)含量的变化及意义。方法采用ELISA法对72例CI及60例MID患者血清中HMGB1、NSE含量进行测定,MID患者的智能水平采用简易智能量表(MMSE)测定,并参考Hachinski缺血评分及DSM-Ⅳ诊断标准进行确诊。结果 CI急性期组患者血清HMGB1、NSE浓度明显高于对照组(P<0.01);而CI恢复期组患者血清HMGB1、NSE的浓度与对照组差异无统计学意义(P>0.05);MID患者HMGB1浓度与对照组及CI恢复期组之间差异无统计学意义(P>0.05);而NSE浓度低于对照组及CI恢复期组(P<0.05)。结论 HMGB1、NSE可反映MID患者脑神经细胞、神经胶质细胞的损害情况和功能状态,对MID患者的病情及预后判断有重要意义。
Objective To study the changes of high mobility groupbox-1（HMGB1） and neuron-specific enolase（NSE） and its significance in the serum of patients with cerebral infarction（CI） and multi-infarct dementia（MID）.Methods The concentrations of serum HMGB1 and NSE were determined in 72 patients with CI and 60 patients with MID by ELISA.Mini-mental state examination（MMSE） was used to examine the intellectual level of MID patients,with Hachinski Ischemia Score and DSM-IV diagnosis standard as references.Results The serum HMGB1 and NSE concentration in acute phase group were significantly higher than that in normal controls respectively（P0.01）;No significant difference was found in HMGB1 and NSE concentration in serum between recovery phase group and normal controls.No significant difference was found in HMGB1 concentration in serum between MID and recovery phase group,normal controls（P0.05）;but NSE was lower than that in normal controls and in recovery phase group（P0.05）.Conclusion HMGB1 and NSE can indicate the suffering situation and functional status of brain nerve cell and glial cell of patients with MID,which is of great significance to patient’s condition and prognosis.
出处
《中华全科医学》
2010年第10期1226-1227,共2页
Chinese Journal of General Practice
