摘要
目的:观察中药汤剂联合分子靶向药物治疗对晚期非小细胞肺癌的治疗效果,观察其对降低副反应发生率的作用。方法:选取2010年5月~2013年5月在我院接受治疗的晚期非小细胞肺癌为研究对象,按随机数字表法将其分为对照组和观察组,对照组给予分子靶向药治疗,观察组在靶向治疗基础上给予中药汤剂。观察两组患者3个月、6个月和1年生存率的差异,比较两组患者治疗前后肿瘤标志物水平和副反应发生率的差异。结果:两组患者3个月、6个月生存率无明显差别,而观察组患者1年生存率明显高于对照组(P<0.05);治疗前两组患者肿瘤标志物水平无明显差异,治疗后两组患者各项肿瘤标志物水平均较治疗前降低;观察组患者血液系统毒性、消化道毒性、肝功能损害和肾功能损害发生率明显低于对照组,差异具有统计学意义(P<0.05)。结论:中药联合分子靶向药治疗对晚期非小细胞肺癌有较好的治疗效果,可明显提高患者生存率,减少副反应的发生。
Objective： To study on the traditional Chinese medicine decoction combined with chemotherapy drugs that target to the therapeutic effect of treatment of early stage non-small cell lung cancer and to reduce the incidence of side effects was ob- served. Methods ： The clinical data of patients with early stage non-small cell lung cancer treated in our hospital from May 2010 to May 2010 were divided into controlled group and observation group according to the random number table method. The controlled group was given chemotherapy targeted therapy, the observation group in the targeted treatment given on the basis of traditional Chinese medicine decoction. 3 months, 6 months and 1 years survival rate of the two groups were observed, and the difference of tumor marker levels and the incidence of side effects of chemotherapy before and after treatment in two groups were compared. Re- suits ： There was no significant difference in survival rate between the two groups in 3 months, 6 months. The 1 year survival rate of the observation group was significantly higher than that of the controlled group （P 〈 O. 05） ; there was no significant difference in the level of tumor markers between the two groups before treatment, the level of tumor markers in the two groups after treatment was lower than before treatment; the blood system toxicity, gastrointestinal toxicity, liver function damage and renal function dam- age in the observation group were significantly lower than those in the controlled group, the difference was statistically significant （ P 〈 0. 05 ）. Conclusion ： Applying traditional Chinese medicine decoction combined with chemotherapy drug target in the treat- ment of early stage non small cell lung cancer have better therapeutic effect, can significantly improve survival rate and reduce the occurrence of side effects.
出处
《四川中医》
2017年第2期101-103,共3页
Journal of Sichuan of Traditional Chinese Medicine
基金
江苏省自然科学课题(编号:JS2014225)
关键词
中药
靶向治疗
非小细胞肺癌
肿瘤标志物
Traditional Chinese medicine
Targeted therapy
Early stage non-small cell lung cancer
Tumor marker
