摘要
目的观察胃癌组织中生存素（Survivin）和基质金属蛋白酶（MMP）-9的表达，探讨胃癌组织中Survivin和MMP-9的表达与胃癌临床病理特点的关系。
方法选择90例胃癌患者胃癌组织标本及其癌旁组织标本做为研究对象，免疫组织化学法检测Survivin和MMP-9在胃癌和癌旁组织中的表达，分析Survivin和MMP-9与胃癌临床病理特点的相关性以及胃癌组织中Survivin和MMP-9表达的关系。
结果胃癌组织中Survivin和MMP-9均呈强阳性表达，胃癌组织中Survivin的阳性率（87.8%）明显高于癌旁组组织（8.9%）（P＝0.000）；胃癌组织中MMP-9的阳性率（78.9%）明显高于癌旁组织（43.3%）（P＝0.000）。胃癌组织中Survivin和MMP-9的表达水平（0.78±0.12、0.75±0.16）高于癌旁组织（0.17±0.09、0.27±0.13）（P＝0.004、0.011）。有淋巴结转移者胃癌组织中Survivin的阳性表达率（85.9%）明显高于无淋巴结转移者（65.4%）（P＝0.022）；临床分期Ⅲ期＋Ⅳ期者胃癌组织中Survivin的阳性表达率（92.3%）明显高于Ⅰ期＋Ⅱ期（60.5%）（P＝0.000）。有淋巴结转移者胃癌组织中MMP-9的阳性表达率（89.1%）明显高于无淋巴结转移者（69.2%）（P＝0.022）；浸润深度T3～T4者胃癌组织中MMP-9的阳性表达率（84.3%）明显高于浸润深度T1～T2者（55.0%）（P＝0.007）；临床分期Ⅲ期＋Ⅳ期者胃癌组织中MMP-9的阳性表达率（96.2%）明显高于Ⅰ期＋Ⅱ期（59.0%）（P＝0.000）。胃癌组织中Survivin和MMP-9表达呈正相关（r＝0.382，P＝0.000）。
结论胃癌组织中Survivin和MMP-9呈高表达，胃癌组织中Survivin的表达和淋巴结转移、临床分期显著相关，胃癌组织中MMP-9的表达和淋巴结转移、浸润深度、临床分期显著相关，胃癌组织中Survivin和MMP-9表达呈正相关。
Objective To study the expression of survival and matrix metalloproteinase -9 （ MMP - 9） in gastric carcinoma, and to investigate the relationship between the expression of survivin and MMP - 9 in gastric carcinoma and clinicopathologieal features of gastric cancer. Methods Selected the gastric cancer tissues and their adjacent tissues of 90 patients with gastric cancer as the objects of the study from January 2014 to December 2015 in Qiqihar Medical Center Pathology. The expression of survivin and MMP -9 in gastric cancer tissues and their adjacent tissues were detected by immunohistoehemical assay. The relationship between the expression of survivin and MMP - 9 in gastric carcinoma and clinicopathologi- cal features of gastric cancer, and the relationship between the expression of survivin and the expression of MMP- 9 in gastric carcinoma were analyzed. Results The Survivin and MMP -9 in gastric carcinoma showed strong positive expression. The positive rate of survivin in gastric carcinoma （87. 8% ） was signifi- cantly higher than that in para- cancerous tissues （8.9% , P =0. 000） ; the positive rate of MMP -9 in gastric tissue （78.9%） was significantly higher than that in adjacent tissues （43.3%, P = 0. 000）. The expression levels of survivin and MMP -9 in gastric carcinoma tissues （0. 78 ± 0. 12, 0. 75 ± 0. 16） MMP-9 were higher than that of the adjacent tissues （0. 17 ± 0.09, 0.27 ±0. 13, P= 0.004, 0. 011 ）. The positive rate of survivin in gastric carcinoma with lymph node metastasis （85.9%） was significantly higher than that in gastric carcinoma without lymph node metastasis （65.4% , P = 0. 022） ; The positive rate of survivin in gastric carcinoma with clinical stage Ⅲ＋Ⅳ stage （92. 3% ） was significantly higher than that in Ⅰ＋Ⅱ stage （60. 5%, P = 0. 000）. The positive rate of MMP -9 in gastric carcinoma with lymph node metastasis （89. 1% ） was significantly higher than that in gastric carcinoma without lymph node metastasis （69. 2%, P = 0. 0
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2017年第2期214-216,共3页
Chinese Journal of Experimental Surgery
关键词
胃癌
生存素
基质金属蛋白酶-9
临床病理特点
Stomach cancer
Survivin
Matrix metalloproteinase - 9
Clinical and pathological features
