摘要
目的探讨甲状腺结节性疾病患者外周血中D-二聚体水平的变化及其临床意义。方法收集普外科住院患者120例,其中甲状腺良性疾病患者60例和甲状腺癌患者60例,采用Sysmex CA7000全自动凝血仪测定患者血浆D-二聚体水平,分析血浆D-二聚体水平与甲状腺癌临床病理特征的关系。结果甲状腺癌患者和甲状腺良性病变患者的D-二聚体水平比较差异无统计学意义(P>0.05)。甲状腺癌患者中,男性与女性、年龄≤44岁与年龄>44岁、不同病理类型之间、肿瘤直径≤1 cm与直径>1 cm、单侧与双侧、有腺外侵犯与无腺外侵犯、有淋巴结转移与无淋巴结转移、Ⅰ期~Ⅱ期与Ⅲ期~ⅥA期患者D-二聚体水平差异均无统计学意义(P>0.05)。结论甲状腺结节性疾病患者处于非高凝状态,血浆D-二聚体与甲状腺癌临床病理无密切相关性。
Objective To explore the changes of D- dimer levels in thyroid nodular and its clinical significance. Methods 120 cases of hospitalized patients in department of general surgery were selected,including 60 cases of thyroid benign nodular and 60 cases of thyroid cancer. Plasma D- dimer level detection was performed on Sysmex CA7000 automatic blood coagulation analyzer. The relationship between clinicopathologic characteristics of thyroid cancer and plasma D- dimer level was analyzed. Results There is no statistical significance on the difference in plasma D- dimer levels between thyroid benign nodular patients and thyroid cancer patients（ P〉0. 05）. For thyroid cancer patients,there is no statistical significance on the differences of plasma D- dimer level between male and female,between ≤44 years old and 〉44 years old,among different pathological types,between tumor diameter ≤ 1 cm and 〉1 cm,between unilateral and bilateral nodular,between with and without extrathyroidal invasion,between with and without lymph node metastasis,between stage Ⅰ- Ⅱ and Ⅲ- ⅥA（ P〈0. 05）. Conclusion The blood of patients with thyroid nodular is in non hypercoagulation state. The plasma D- dimer level has no correlation with clinicopathologic characteristics of thyroid cancer.
出处
《中国卫生检验杂志》
CAS
2017年第3期366-367,407,共3页
Chinese Journal of Health Laboratory Technology
基金
浙江省医药卫生科技项目(2011KYB104)
