摘要
目的探讨正常人群同型半胱氨酸(HCY)水平及影响因素。方法回顾性分析2015年7—9月在浙江省人民医院健康体检的正常居民1 239人,其中HCY>15μmol/L为高HCY组,HCY≤15μmol/L为正常对照组。分析两组血脂、血糖、尿酸(UA)、血小板计数(PLT)和血红蛋白(HBG)水平。结果 1 239人中检出高HCY 564例,检出率为45.52%,男性474例,检出率为60.69%;女性90例,检出率为19.65%。单因素分析显示,高HCY组高密度脂蛋白胆固醇(HDL)、UA、HBG、PLT、血小板平均压积(PCT)指标与对照组比较,差异均有统计学意义(P<0.05);多因素Logistic回归分析显示,高HCY的发生与UA(OR=1.006,95%CI:1.005~1.008)、HBG(OR=1.035,95%CI:1.026~1.045)呈正相关,而与PLT(OR=0.996,95%CI:0.993~0.998)呈负相关。结论高UA、HBG水平和低PLT水平与高HCY密切相关,可作为尽早发现高HCY的重要途径。
Objective To investigate the level of homocysteine among healthy examination people and the possible related factors. Methods Retrospective analysis was performed to collect 1 259 results of healthy examination people from July to September in 2015, and 564 patients were confirmed to be hyperhomocysteinemia. The serum level of lipoids, glucose, uric acid and blood routine results were also collected. Results The incidence of hyperhomocysteinemia was 45. 52% , and man has a higher rate than woman. The results of logistic regression showed positive results of UA （ OR = 1. 0 0 6 , 95% CI= 1.005 -1.008） , HBG（OR = 1.035, 95% CI = 1.026 -1.045）, and PLT （OR = 0 .9 9 6 , 95% CI= 0 .9 9 3 - 0 .9 9 8 ） in high hyperhomocysteinemia patients. Conclusion High UA,HBG and low PLT levels are risk factors in hyperhomocysteinemia, and could be the important way for the early diagnoses of hyperhomocysteinemia.
出处
《预防医学》
2017年第3期248-250,共3页
CHINA PREVENTIVE MEDICINE JOURNAL
