摘要
目的研究阿立哌唑在酸性溶液中的降解动力学。方法通过经典恒温实验,采用HPLC法测定阿立哌唑在不同温度、pH值、缓冲液种类及质量浓度的降解动力学参数,用Arrhenius公式预测其活化能。结果阿立哌唑在酸性溶液中最稳定的pH值为4.0。随着温度增加,阿立哌唑的降解加快,其活化能Ea=117.60kJ·mol^(-1)。阿立哌唑在枸橼酸盐中的降解速率最快,在磷酸盐及醋酸盐中相对较慢。结论阿立哌唑在酸性溶液中的降解近似一级动力学过程,与温度和缓冲盐质量浓度呈正相关,pH值对其降解速率影响显著,缓冲盐种类的不同对其降解速率影响较明显。本研究为该制剂的研究开发提供了必要的数据支持。
To study the aripiprazole degradation kinetics in acidic solution. Classic isothermal method was em-ployed to evaluate the degradation kinetic profiles under different temperatures, pH values, buffer types and concentrations. The Arrhenius formula was used to predict the activation energy. In acidic solution, aripiprazole was the most stable at pH4.0. The degradation rate increased with the increase of temperature, with the active energy Ea = 117.60 kJ·mol^-1. The degra-dation rate of aripiprazole in citrate was the fastest and is relatively slow in phosphates and acetates. Aripiprazole deg-radation in acidic solution was fitted to the first-order kinetic model. Moreover,its degradation remarkably and positively correla-ted with temperature and buffer salt concentration. pH also had obvious effect on the degradation rate and different types of buffer salts had a significant impact on its degradation. The kinetic profiles provide the necessary data support for the future pharmaceu-tical research.
出处
《西北药学杂志》
CAS
2017年第2期194-197,共4页
Northwest Pharmaceutical Journal
基金
陕西省食品药品快速检测公共服务平台建设项目(编号:2014FWPT-01)
关键词
阿立哌唑
降解动力学
经典恒温法
稳定性
aripiprazole
degradation kinetics
classic isothermal method
stability
