摘要
基于COMSOL Multiphysics5.2仿真模型,数值模拟了在宽100μm的微通道中以水力聚焦形式形成单列细胞流,并在聚二甲基硅氧烷(PDMS)作为主体材料的微流控芯片实验中得到验证。在COMSOL仿真软件中建立层流、粒子追踪模块物理场,通过建立二维模型对十字通道状态下的两种微粒进行水力聚焦仿真,并在设计加工芯片基础上搭建水力聚焦实验系统。发现无论是在仿真软件还是实际的实验系统中,通过调节鞘液通道和主通道的层流速度比例可以有效控制中心层流宽度;并且不同的粒子在相同的流体中所受到的阻力只与细胞的直径和流速有关,与其他参数无关。
Based on COMSOL Multiphysics5.2 simulation model,the formation of a single cell laminar flow was simulated in100μm width microchannel in the form of hydrodynamic focusing,and was verified in the microfluidic chip experiment with polydimethylsiloxane（PDMS）as the main material.The laminar flow and particle tracking module physical field were built in COMSOL simulation software.Through establishing a two-dimensional model,the hydrodynamic focusing simulations of two kinds of particles under the cross channel status were carried out,and the hydrodynamic focusing experimental system was constructed on the basis of processing chip design.It is found that the width of the center flow can be effectively controlled by adjusting the laminar liquid velocity ratio of the sheath fluid channel and the main channel in the simulation software and the actual experimental system.Moreover,the resistance force of different particles in the same fluid only is dependent of the cell diameter and flow velocity,and is independent of other parameters.
出处
《微纳电子技术》
北大核心
2017年第3期168-172,180,共6页
Micronanoelectronic Technology
基金
河北省青年科学基金资助项目(B2014202260)
