摘要
目的 :观察痤疮合剂对痤疮的疗效,并初步探求其治疗痤疮的作用机制。方法 :家兔耳廓部造模成功后,将家兔分为6组进行治疗。通过观察局部外观变化并检测血清中IL-8、TNF-α含量证实痤疮合剂对痤疮动物的炎症抑制作用。结果 :与正常对照组比较,其余5组IL-8、TNF-α含量均显著升高;与模型对照组比较,痤疮合剂低、中、高剂量组及药物对照组炎症因子含量均显著下调,且高剂量组含量的下调更为显著(P<0.01)。结论 :痤疮合剂治疗痤疮呈量效依赖关系,其作用机制可能与抑制血清中相关炎症因子水平有关。
Objective： To observe the effect of acne mixture on acne and preliminarily explore its mechanism in the treatment of acne. Methods： The rabbits were divided into 6 groups to be treated after the modeling succeeded. The inhibition of acne mixture to the inflammation of experimental animals was verified by the observation of the changes of local appearance and the determination of IL-8 and TNF-α levels in serums. Results： Compared with normal control group, the IL-8 and TNF-α levels five groups were significantly higher in the other 5 groups than in the control group （P 〈 0.01） and the levels of inflammatory factors were significantly down-regulated in the groups with low, medium and high dose of acne mixture compared with the model group （P 〈 0.01）, and furthermore their down-regulation was more significant in the high dose group than in the low and medium groups. Conclusion： The efficacy of ache mixture for the treatment of acne presents dose-dependent relationship and its mechanism of action may be related to the inhibition of the levels of inflammatory factors in serum.
作者
张琳
顾炜
朴美淑
吴景东
ZHANG Lin GU Wei PIAO Meishu WU Jingdong(93279 Forles Political Office, Dandong 118000, China the Hospital affiliated to Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China Korean Wonkwang University, Seoul, Korea Liaoning University of Traditional Chinese Medicine, Shenyang 110847, China)
出处
《上海医药》
CAS
2017年第3期65-68,共4页
Shanghai Medical & Pharmaceutical Journal
基金
辽宁省教育厅科学研究项目(课题编号L2014363)
