摘要
目的观察小剂量多巴酚丁胺早期干预治疗肺炎合并脓毒症的效果。方法 53例肺炎合并脓毒症患儿为研究对象,随机分为治疗组（26例）和对照组（27例）,两组均于入院后2 h内给予静脉滴注抗生素,必要时给予静脉滴注丙种球蛋白（丙球）、甲泼尼龙（甲强龙）及呼吸机辅助通气等治疗;治疗组在上述治疗的同时加用小剂量多巴酚丁胺泵入[剂量2-5μg/（kg·min）],早期干预治疗,应用前先纠正低血容量。结果治疗组器官衰竭的发生率为15.38%（4/26）,无死亡病例,平均住院时间（14.6±3.3）d,呼吸困难消失时间为（3.2±0.9）d,血压稳定时间为（4.5±0.9）d;对照组器官衰竭的发生率为48.15%（13/27）,死亡4例（14.81%）,平均住院时间（21.4±6.2）d,呼吸困难消失时间为（7.6±2.3）d,血压稳定时间为（8.8±1.9）d。两组器官衰竭发生率及病死率、住院时间、呼吸困难的消失时间、血压稳定时间比较,差异均有统计学意义（P〈0.05）。结论小剂量多巴酚丁胺早期干预治疗肺炎合并脓毒症,可降低器官衰竭的发生率及病死率,缩短住院时间。值得同仁借鉴。
Objective To observe effect of small dose dobutamine for early interventing treatment of pneumonia complicated with sepsis. Methods A total of 53 pneumonia complicated with sepsis children as study subjects were randomly divided into treatment group （26 cases） and control group （27 cases）. Both groups received intravenous drip of antibiotics within 2 h after hospital admission, and intravenous drip of gamma globulin and methylprednisolone, respirator assisted ventilation were given if necessary. The treatment group also had small dose dobutamine [ dosage as 2-5 μg/（kg · min） ] pumping for early intervention, and all this was done before correction of hypovolemia. Results The treatment group had incidence of organ failure as 15.38% （4/26）, 0 dead case, mean hospital stay time as （14.6 ± 3.3） d, breathing difficulties disappear time as（3.2 ± 0.9）d, blood pressure stable time as （4.5 ± 0.9）d, which were 48.15% （13/27）, 4 cases （14.81%）, （21.4 ± 6.2）d, （7.6 ± 2.3）d and （8.8 ± 1.9）d in the control group. There were statistically significant difference in incidence of organ failure and mortality, hospital stay time, breathing difficulties disappear time, blood pressure stable time in two groups （P〈0.05）.Conclusion Small dose dobutamine for early interventing treatment of pneumonia complicated with sepsis can reduce incidence of organ failure and mortality, and short hospital stay time. It is worth referring.
出处
《中国实用医药》
2016年第36期116-118,共3页
China Practical Medicine
