摘要
目的:观察低强度全身复合振动(whole-body vibration,WBV)联合阿仑膦酸钠(alendronate,ALE)对绝经后骨质疏松患者骨密度的影响情况。方法:选择2014年8—12月门诊绝经后骨质疏松患者60例,随机分为WBV治疗组、ALE治疗组和WBV+ALE治疗组,每组20例;WBV治疗组是给予全身低强度复合振动(振动强度为0.5—0.8g,频率为45—55Hz,每次振动30min,每天1次,每周5次,周末休息2天,共6个月);ALE治疗组是每周口服1次阿仑膦酸钠70mg;WBV+ALE治疗组是给予全身复合振动及阿仑膦酸钠治疗。然后使用双能X线吸收骨密度仪测定所有志愿者治疗前后腰椎及髋部的骨密度。结果:(1)腰椎骨密度在WBV治疗6个月后增加3.72%,ALE治疗组增加4.55%,WBV+ALE治疗组增加7.16%,三组治疗方法之间有显著性差异(P<0.05)。(2)髋部Neck骨密度,WBV治疗6个月后增加2.24%,ALE治疗组增加3.43%,WBV+ALE治疗组增加7.22%,三组治疗方法比较有显著性差异(P<0.05)。(3)大转子骨密度,WBV治疗6个月后增加2.10%,ALE治疗组增加4.90%,WBV+ALE治疗组增加7.63%,三组治疗方法之间比较有显著性差异(P<0.05)。(4)髋部Wards三角骨密度,WBV治疗6个月后增加5.00%,ALE治疗组增加7.13%,WBV+ALE治疗组增加9.04%,三组治疗方法之间比较有显著性差异(P<0.05)。结论:WBV、ALE和WBV+ALE三种治疗方法均能改善绝经后老年妇女腰椎及髋部的骨密度,其中低强度WBV联合ALE能够更好提高绝经后腰椎及髋部BMD,可以为临床上绝经后骨质疏松的防治工作提供一种新的思路。
Objective： To observe the bone mineral density for patients with postmenopausal osteoporosis treated by lowmagnitude whole-body vibration and alendronate.Method： A total of sixty postmenopausal osteoporotic women were randomly divided into three groups（WBV n=20, ALE n=20 and WBV ＋ ALE n=20）. The level of WBV applied was 0.5—0.8 g at 45—55 Hz for 6months（30min/d, 5d/week）. ALE was administered in dose of 70 mg once a week. The BMD of lumbar（L2—L4）, femoral neck, anter, and wards triangle region of hip was determined by dual-energy X-ray absorptiometry before and after treatment.Result：（1） The BMD in lumbar 2—4 after 6-months treatment showed that the average BMD was increased by 3.72% in WBV-group, by 4.55% in ALE-group, and by 7.16% in WBV＋ALE-group. There were significant differences among three groups（P〈0.05）.（2） The BMD in femoral neck after 6-months treatment showed that the average BMD was increased by 2.24% in WBV-group, by 3.43% in ALE-group, and by 7.22% in WBV＋ALE-group. There were significant differences among three groups（P〈0.05）.（3）The BMD in anter of hip after 6-months treatment showed that the average BMD was increased by 2.10% in WBV-group, by 4.90% in ALE-group, and by 7.63% in WBV ＋ ALE-group. There were significant differences among three groups（P〈0.05）.（4） The BMD in wards triangle region of hip after 6-months treatment showed that the average BMD was increased by 5.00% in WBV-group, by 7.13% in ALE-group, and by 9.04% in WBV＋ALE-group. There were also significant differences among three groups（P〈0.05）.Conclusion： Whole-body vibration, alendronate and combination treatment can increase the BMD in postmenopausal osteoporotic women, significantly. Furthermore, whole-body vibration combined with alendronate was more effective in improving the BMD in postmenopausal women.
出处
《中国康复医学杂志》
CAS
CSCD
北大核心
2017年第2期182-186,共5页
Chinese Journal of Rehabilitation Medicine
基金
福建省医学创新课题资助项目(2014-CXB-31)
福建莆田市科技局资助项目(2012S01)
关键词
全身复合振动
阿仑膦酸钠
骨质疏松症
绝经后妇女
骨密度
whole-body vibration
Alendronate
osteoporosis
postmenopausal women
bone mineral density
