摘要
目的研究分析利培酮联合无抽搐电休克治疗难治性精神分裂症的临床效果。方法 68例难治性精神分裂症患者,随机分为对照组与实验组,各34例。对照组单纯使用利培酮治疗,实验组在利培酮治疗的基础上采用无抽搐电休克治疗,对两组患者的治疗效果及阳性和阴性症状量表(PANSS)评分进行对比分析。结果两组患者治疗后的PANSS评分均较治疗前明显下降,差异具有统计学意义(P<0.05)。治疗后,实验组患者PANSS评分为(38.8±2.8)分,明显低于对照组的(52.7±3.4)分,差异具有统计学意义(P<0.05)。对照组治疗总有效率为70.6%,明显低于实验组的91.2%,差异具有统计学意义(P<0.05)。结论在难治性精神分裂症患者中,采用利培酮联合无抽搐电休克治疗,可以显著的提高治疗效果,其不良反应少,具有较高的安全性与可靠性,值得临床推广应用。
Objective To research and analyze clinical effect by risperidone combined with modified electroconvulsive therapy in the treatment of refractory schizophrenia. Methods A total of 68 patients with refractory schizophrenia were randomly divided into control group and experimental group, with 34 cases in each group. The control group received risperidone for treatment alone, and the experimental group received additional modified electroconvulsive therapy to risperidone for treatment. Comparative analysis was made on curative effects and positive and negative syndrome scale（PANSS） scores between the two groups. Results Both groups had obviously lower PANSS scores after treatment than those before treatment, and the difference had statistical significance（P〈0.05）. After treatment, the experimental group had PANSS score as（38.8±2.8） points, which was obviously lower than（52.7±3.4） points in the control group, and the difference had statistical significance（P〈0.05）. The control group had much lower total effective rate as 70.6% than 91.2% in the experimental group, and the difference had statistical significance（P〈0.05）. Conclusion Implement of risperidone combined with modified electroconvulsive therapy in the treatment of refractory schizophrenia can remarkably improve curative effect, along with few adverse reactions, high safety and creditability. It is worth clinical promotion and application.
出处
《中国现代药物应用》
2017年第1期104-106,共3页
Chinese Journal of Modern Drug Application
关键词
利培酮
无抽搐电休克
难治性精神分裂症
临床研究
Risperidone
Modified electroconvulsive therapy
Refractory schizophrenia
Clinical research
