摘要
目的观察无抽搐电休克(MECT)与传统电休克(ECT)治疗精神分裂症患者急性兴奋的疗效和安全性。方法将急性精神分裂症兴奋患者71例随机分为MECT组(治疗组)和ECT组(对照组),共治疗5次,采用阳性和阴性症状量表(PANSS)中兴奋因子(PANSS-EC)的变化评定临床疗效,副反应量表(TESS)评定不良反应,治疗前及治疗后分别评定血、尿、生化常规及心电图、血清CPK。结果 MECT组的PASS-EC总分明显降低,PASS-EC减分率(71±27)%,临床总有效率52.7%;ECT组PANSS-EC减分率(67±24)%,临床总有效率45.7%,2组间差异均无统计学意义(P均>0.05)。MECT组总的不良反应发生率41.7%,ECT组为54.3%,2组差异无统计学意义(P>0.05)。ECT组的头晕、头痛、肌肉酸痛发生率明显高于MECT组,差异有统计学意义(P<0.05或<0.01)。结论MECT治疗精神分裂症急性兴奋疗效肯定,安全性高。
Objective To determine the efficacy and safety of injection MECT in the treatment of acute agitation in schizophrenia.Methods Seventy-one inpatients were randomly divided into MECT group and ECT group,36 patients were treated with MECT injection and 35 were treated with ECT injection.The positive and negative syndrome scale（PANSS）,PANSS-exiciting factor（PANSS-EC） and treatment emergent symptom scale（TESS） were used to evaluate the efficacy and side-effect.Results The total score of PANSS-EC in the MECT group was significantly reduced.There were no significant differences in the reduction of PANSS-EC score [（71±27）% vs.（67±24）%] and the response rates（52.7% vs.45.7%）between the MECT and haloperidol group（P0.05）.The total incidence of side effects in MECT group was not significantly different from ECT group（41.7% vs.54.3%）.Conclusion MECT is effective and safe in treating acute agitation schizophrenia.
出处
《中国实用神经疾病杂志》
2011年第13期13-15,共3页
Chinese Journal of Practical Nervous Diseases
