摘要
目的探讨心脏型脂肪酸结合蛋白(H-FABP)、肌钙蛋白I(c Tn I)和肌酸激酶(CK-MB)对急性心肌梗死(AMI)早期诊断的价值。方法选取2014年6月-2015年7月100例疑似AMI的患者为研究对象,其中入院后确诊AMI 54例,NAMI 46例。检测患者的H-FABP、c Tn I、CK-MB水平,分析和比较3种标志物对早期确定AMI诊断意义的差异性。结果 H-FABP检测AMI的灵敏度为88.9%,高于c Tn I及CK-MB,差异有统计学意义;H-FABP检测AMI的特异度为91.3%,高于CK-MB,差异有统计学意义;H-FABP检测AMI的阴性预测率为87.5%,高于c Tn I以及CK-MB;H-FABP检测AMI的阳性预测率为92.3%,显著高于CK-MB,上述差异均有统计学意义(P<0.05);H-FABP检测AMI的正确指数最高,为0.801。结论 H-FABP对早期AMI诊断具有较高的准确性、灵敏性及特异性,可作为可疑AMI患者鉴别诊断的重要参考指标。
Objective To analyze the clinical value of heart type fatty acid binding protein（ H- FABP）,cardiac troponin I（ c Tn I） and creatine kinase- MB（ CK- MB） in the diagnosis of early acute myocardial infarction（ AMI）. Methods From June,2014 to July,2015,100 cases with suspected AMI were selected as the research subjects,including 54 cases of confirmed AMI after admission and 46 cases of non- AMI. The levels of H- FABP,c Tn I and CK- MB were detected in AMI subjects,and then the differences of the 3 biomarkers were compared and analyzed in the diagnosis of early AMI. Results The sensitivity of H- FABP detection was 88. 9% in AMI,which was higher than that of cardiac troponin I and CK- MB,with the differences statistically significant（ P〈0. 05）. The specificity of H- FABP in the detection of AMI was 91. 3%,which was higher than CK- MB,and the differences had statistical significance（ P〈0. 05）; the negative predictive rate of H- FABP in the detection of AMI was 87. 5%,which was higher than c Tn I and CK- MB（ P〈0. 05）; the positive predictive rate of H-FABP was 92. 3%,which was higher than CK- MB（ P〈0. 05）. The correct rate of H- FABP in the detection of AMI was up to 0. 801. Conclusion H- FABP has high accuracy,sensitivity and specificity in the diagnosis of early AMI,which can be referred as an important reference index for the diagnosis of AMI patients.
出处
《中国卫生检验杂志》
CAS
2017年第2期211-213,共3页
Chinese Journal of Health Laboratory Technology
