摘要
目的探讨可溶性成纤维细胞活化蛋白(sFAP)在肺癌患者外周血中的表达及其临床意义。方法抽取74例肺癌患者和74例健康人群的外周血,采用ELISA法检测sFAP的表达,电化学发光免疫分析法检测肿瘤标志物,并绘制ROC曲线,分析sFAP与临床特征及肿瘤标志物的相关性。结果 sFAP在肺癌患者外周血中的表达高于健康人群(P<0.01)。肺癌患者sFAP的高表达与淋巴结转移有关(P<0.05),未发现与患者性别、年龄、病理类型、肿瘤分期、远处转移有关(P>0.05)。以sFAP为1.07ng/ml作为最佳诊断界值时,检测肺癌的灵敏度为85.1%,特异度为86.3%;以联合干预因子为0.99作为最佳诊断界值时,sFAP联合肿瘤标志物检测肺癌的灵敏度为94.6%,特异度为89.2%。结论 sFAP在肺癌患者外周血中高表达,且与肺癌的淋巴结转移密切相关;动态监测sFAP可预测肺癌的疗效和预后。
Objective To investigate the expression and clinical significance of soluble fibroblasts activation protein（sFAP）in peripheral blood of patients with lung cancer.Methods sFAP expression in peripheral blood was detected by ELISA in 74 patients with lung cancer（group A）and74 healthy people（group B）.The tumor markers were measured by electrochemiluminescence immunoassay as well.Using ROC curves,the relationship of sFAP with clinical characteristics and tumor markers was analyzed.Results sFAP expression in peripheral blood of patients with lung cancer was higher in group A than that in group B（P〈0.01）.High expression of sFAP in the patients of group A was correlated with lymph node metastasis（P〈0.05）,but was not relevant to sex,age,pathological type,tumor stage and distant metastasis（P〉0.05）.Taking sFAP 1.07ng/ml as the best cut-off value,the sensitivity and specificity in the detection of lung cancer were 85.1% and 86.3%,respectively.Taking combining predictor 0.99 as the best cut-off value,the sensitivity and specificity in the detection of lung cancer were 94.6% and 89.2%,respectively when combined detection of serum sFAP and the tumor markers.Conclusion sFAP in peripheral blood is highly expressed and closely related to lymph node metastasis in the patients with lung cancer.Dynamic monitoring of sFAP may be valuable in evaluating clinical efficacy and predicting the prognosis of patients with lung cancer.
出处
《江苏医药》
CAS
2017年第2期84-87,共4页
Jiangsu Medical Journal
基金
国家自然科学基金(81272610)
苏州市科技发展计划基金(SYS201467)
苏州大学附属第二医院青年职工预研基金(SDFEYQN1617)
关键词
肺癌
可溶性成纤维细胞活化蛋白
Lung cancer
Soluble fibroblasts activation protein
