摘要
目的探讨抗中性粒细胞胞浆抗体（ANCA）相关性小血管炎（AASV）肾损害中医证型分布特点及与实验室指标的相关性，为中医辨证分型及辨证施治提供客观的理论依据。方法采用回顾性分析的研究方法，选取90例AASV肾损害的住院病例，进行中医分型后，根据中医证候兼夹情况将90例病例分成4组进行分组研究。结果中医辨证分型调查结果显示：以单纯虚证存在者少（仅8例），多兼夹浊瘀证（67例），其次为风湿证（28例）。实验室指标显示，在中医各证型组间，24h尿蛋白定量、血肌酐水平、贫血程度均以虚＋浊瘀＋风湿证组最严重；血C反应蛋白（CRP）以虚＋风湿证组最高，纯虚证组最低。各中医证型组的BVAS积分由高到低，依次为：虚＋风湿证、虚＋风湿＋浊瘀证、虚＋浊瘀证、纯虚证。结论虚证贯穿AASV肾损害疾病始终，但单纯虚证者少，虚证中兼夹浊瘀最多、其次为风湿证。在AASV肾损害中医分型中，虚证代表了疾病的慢性化基础和疾病最终的转归，风湿证代表了疾病的急性活动性病变，而浊瘀证代表了相对慢性化病变，虚证兼夹风湿、浊瘀证为疾病肾功能损伤最严重阶段。
Objective To explore the ANCA associated vasculitis （ AASV ） renal damage distribution characteristic of TCM syndrome and correlation with laboratory parameters, and provide a theoretical basis for the objective of TCM type and dialectical therapy. Methods 90 cases of AASV were selected and divided into 90 groups according to the TCM syndrome types. The cases were divided into 4 groups according to the retrospective analysis of the research methods. Results The Chinese medicine dialectical classification survey results show that： in the case of simple deficiency syndrome （ only 8 cases ） , and more than 67 cases ofstasis syndrome （ cases ） , followed by rheumatic syndrome （ 28 cases ） . Laboratory indicators showed that in the TCM syndrome type groups, 24h urine protein, serum creatinine level, the degree of anemia were deficiency ＋ phlegm stasis rheumatism ＋ syndrome group the most serious; CRP blood deficiency ＋ rheumatism card group was the highest, the lowest pure deficiency group. （ 3 ） the BVAS score of each TCM syndrome type group was from high to low, followed by： deficiency of rheumatism, deficiency of Qi and blood stasis, deficiency of Qi and blood stasis, deficiency of qi. Conclusions The syndrome of deficiency in the AASV kidney damage disease is always throughout the whole process, but for the merely deficiency syndrome alone is rare, and the syndrome of deficiency of Qi and blood stasis is the most, followed by rheumatism.AASV in renal damage syndrome, deficiency syndrome represents the result ofthe disease ofchronic foundation disease and eventually, rheumatism card represents the acute disease lesion, while the turbid stasis represents the relative deficiency of the chronic lesions, and clip rheumatism, blood stasis turbid disease renal injury is the most serious stage.
出处
《浙江临床医学》
2017年第2期311-313,共3页
Zhejiang Clinical Medical Journal
关键词
相关性小血管炎肾损害
中医辨证分型
实验室指标
Associated small vessel vasculitis with renal damage Traditional Chinese medicine dialectical typing Laboratory index
