摘要
目的:探讨脾胃培源灌肠方治疗脾气虚弱型溃疡性结肠炎的临床疗效与安全性。方法:将48例UC患者随机分为治疗组与对照组,每组各24例,治疗组予以脾胃培源灌肠方灌肠加上美沙拉嗪肠溶片口服治疗,对照组单纯的给予美沙拉嗪肠溶片口服治疗,2组疗程皆为60d。结果:治疗组有效率为91.67%,对照组有效率为70.83%,2组差异具有统计学意义(P<0.05);治疗组在中医临床症状缓解率、内镜下肠黏膜充血水肿、出血点、血管模糊缓解率及血清C-反应蛋白水平变化上均优于对照组,治疗组在内镜下肠黏膜糜烂、溃疡、颗粒样改变缓解率上与对照组比较(P>0.05),差异无统计学意义。治疗期间,对照组有3例出现不良反应,治疗组未出现不良反应。结论:脾胃培源灌肠方灌肠联合美沙拉嗪口服治疗脾气虚弱型UC临床疗效良好,不良反应相对较少,值得临床借鉴与应用。
Objective： To explore the clinical efficacy and safety of Piwei Peiyuan Enema in the treatment of ulcera- tive colitis with deficiency of spleen Qi. Methods： 48 patients with UC were randomly divided into treatment group and control group, each group of 24 cases. The treatment group was given Piwei Peiyuan Enema plus Mesalazine Enteric- coated Tablets. The control group was treated with Mesalazine enteric-coated tablets alone. The course of treatment was 60 days in both groups. Results： The effective rate of the treatment group was 91.67%, the effective rate of the control group was 70.83%, the difference was statistically significant （P 〈0.05）. The clinical symptom remission rate, edema and bleeding of the intestinal mucosa and there was no significant difference in remission rate of intestinal mucosal erosion, ulcer and granulomatosis between the treatment group and the control group （P〉 0.05）. During the treatment, the control group 3 cases of adverse reactions, the treatment group did not appear adverse reactions. Conclusion： Pi- wei Peiyuan Enema combined with mesalazine has good clinical efficacy and less side-effect in treating deficiency of spleen Qi type UC. It is worthy of clinical reference and application.
作者
李学军
王兴
孙琴
李永帅
叶莎莎
LI Xuejun WANG Xing SUN Qin LI Yongshuai YE Shasha(The Second Affiliated of Anhui University of Chinese Medicine, Anhui Hefei 230061, China Anhui University of Chinese Medicine, Anhui Hefei 230038, China)
出处
《中医药临床杂志》
2017年第1期110-112,共3页
Clinical Journal of Traditional Chinese Medicine
基金
国家中医药管理局重点专科建设项目
安徽省中医药管理局重点专科建设项目
