摘要
为探讨自拟愈溃汤保留灌肠治疗溃疡性结肠炎的临床疗效,选取本院就诊的溃疡性结肠炎患者60例,按随机数字法分为观察组和对照组,各30例。对照组给予美沙拉秦常规治疗。观察组在对照组治疗基础上,加以自拟愈溃汤保留灌肠。比较2组临床疗效、不良反应发生率及治疗前后血清TNF-α、IL-β水平。结果显示,治疗后观察组总有效率为93%,对照组为73%,2组比较差异有统计学意义(P <0.05);观察组血清TNF-α、IL-β改善程度显著优于对照组,不良反应发生率低于对照组,2组比较差异均有统计学意义(均P<0.05)。结果表明,自拟愈溃汤保留灌肠治疗溃疡结肠炎效果显著,能提高总有效率,改善患者TNF-α、IL-β水平,降低不良反应发生,值得临床上推广应用。
This study was to investigate the clinical effect of self-developed Yukui Tang(a TCM formula,shortened to Tang)for retention enema in the treatment of ulcerative colitis(UC),enrolled 60 UC patients who received treatment in author’s hospital,and randomly divided them into observation group(30 cases,treated with mesalazine plus the Tang for retention enema)and control one(30 cases,alone mesalazine),them compared clinical effect,the incidence of untoward reactions,and the levels of serum TNF-αand IL-βbefore and after treatment between the two groups.As results,in total effective rate in the incidence of untoward reaction,and in improvement of serum TNF-αand IL-βlevel,observation group was respectively and significantly higher(93.% vs 73%)lower than and superior to control group(all,P <0.05).Results show that the Tang for retention enema has significant effect on UC,including enhancing total effective rate,improving the level of TNF-αand IL-β,declining the incidence of untoward reactions.It is worthy of clinical popularization and application.
作者
王凯
杨亚娟
刘利萍
WANG Kai;YANG Ya-juan;LIU Li-ping(Henan Provincial Hospital of TCM,Zhengzhou,Henan 450002;Henan University of TCM,Zhengzhou,Henan 450002)
出处
《中国肛肠病杂志》
2019年第6期38-40,共3页
Chinese Journal of Coloproctology
关键词
溃疡性结肠炎
自拟愈溃汤
保留灌肠
疗效
Ulcerative colitis
Self-developed Yukui Tang
Retention enema
Effect
