摘要
目的:探讨免疫调节剂对难治性癫痫患儿免疫球蛋白及T细胞亚群的影响。方法选取2013年6月~2016年6月我院收治的82例难治性癫痫患儿作为研究对象,随机分为观察组和对照组,各41例,对照组接受常规抗癫痫药物治疗,用药方案均为联合服用2种以上抗癫痫药物,但不使用免疫调节剂,观察组在常规治疗基础上联用免疫球蛋白,用量以400mg·kg^(-1)·d^(-1)为标准,连续治疗5d为1个疗程,每个月进行1个疗程,共进行3个月,比较两组治疗前后的IgA、IgG、IgM水平及CD3^+、CD4^+、CD8^+、CD4^+/CD8^+的变化。结果治疗前,两组IgA、IgG、IgM水平无统计学差异(P>0.05)。治疗后,观察组IgA、IgG水平均高于治疗前,差异均有统计学意义(P均<0.05),而IgM水平无显著变化(P>0.05),对照组IgA、IgG、IgM水平与治疗前差异无统计学意义(P>0.05),观察组IgA、IgG水平显著高于对照组,差异有显著性(P<0.05),而两组间IgM水平差异无统计学意义(P>0.05)。治疗前,两组CD3^+、CD4^+、CD8^+、CD4^+/CD8^+均无统计学差异(P>0.05)。治疗后,观察组CD3^+、CD4^+、CD4^+/CD8^+水平较治疗前高,CD8^+较治疗前低,差异均有统计学意义(P均<0.05),对照组CD3^+、CD4^+、CD8^+、CD4^+/CD8^+水平与治疗前比较差异无统计学意义(P>0.05)。观察组CD3^+、CD4^+、CD4^+/CD8^+水平显著高于对照组,CD8^+显著低于对照组,差异有统计学意义(P<0.05)。结论与单用常规抗癫痫药物相比,应用免疫球蛋白作为免疫调节剂结合常规抗癫痫药物治疗难治性癫痫患儿可有效改善其IgA、IgG、IgM水平及T细胞亚群的表达,对患儿的免疫功能有积极影响。
Objective：To observe the influence of immunomodulator on the immunoglobulin and T cell subsets in children with intractable epilepsy.Method：A total of 82 children with intractable epilepsy in our hospital were selected and randomly divided into 2groups：the control group（41cases）and the observation group（41cases）.Routine antiepileptic drugs were given to the control group.Medication regimen was that more than 2kinds of anti epileptic drugs were be combined used.But the immunomodulator wasn＇t used.Treatment of immune globulin was given to the control group on the basis of observation group.Taking 400mg·kg-1·d-1as the standard of dosage,5consecutive days as a course of treatment.One course of treatment was carried out every month,3 months in total.The changes of IgA、IgG、IgM and CD3＋,CD4＋,CD8＋,CD4＋/CD8＋were compared in 2groups before and after treatment.Results：The comparison of IgA,IgG,IgM in the two groups be-fore treatment was not statistically significant（P〈0.05）.After treatment,IgA,IgG in observation group were significantly higher than that before treatment and the difference was statistically significant（P〈0.05）.However,there was no significant difference on the IgM（P〈0.05）.There was no significant difference on the IgA,IgG,IgM in the control group compared with that before treatment（P〈0.05）.IgA,IgG in observation group was significant higher than that in the control group（P〈0.05）.The comparision of IgM between 2groups was not statistically significant（P〈0.05）.The comparison of CD3＋,CD4＋,CD8＋,CD4＋/CD8＋in the two groups before treatment was not statistically significant（P〈0.05）.After treatment,CD3＋,CD4＋,CD4＋/CD8＋in observation group were significantly higher than that before treatment;CD8＋in observation group was significantly lower than that before treatment.The difference was statistically significant（P〈0.05）.There was no significant difference on the CD3＋,CD4＋,CD8＋,CD4＋/CD8＋in the control group com
作者
高阳
GAO Yang(Department of Neurosurgery, the Third People＇s Hospital of Mianyang , Mianyang City 621000, Sichuan Province, China)
出处
《海南医学院学报》
CAS
2017年第4期553-555,559,共4页
Journal of Hainan Medical University
基金
四川省科技厅资助项目(2015SV0271)~~
