摘要
目的探讨肺表面活性物质（Ps）治疗在发生或可疑发生的早产儿呼吸窘迫综合征（RDS）的临床疗效。方法32例在发生或可疑发生的RDS患儿随机分为两组：治疗组和对照组，治疗组17例，对照组15例，治疗组采用固尔苏治疗，用药后给予鼻塞式持续气道正压通气（CPAP）辅助呼吸；对照组除不予固尔苏治疗外，余治疗同治疗组。结果治疗组PaO2、PaCO2、pH与对照组比较，有显著性差异（P〈0．05），治疗组并发症及死亡率明显低于对照组（P〈0．05）。治疗组用CPAP时间及住院天数与对照组比较，有显著性差异（P〈0．05）。结论早期应用PS治疗RDS，可以减少用药次数，减少机械通气，减轻病人的负担，减少并发症的发生，提高患儿的生存质量。
Objective To study the efficacy of Pulmary surfactant in treatment to the respiratory distress syndrome of neonates, which were on RDS or should be on RDS. Methods Thirty - two neonates who were on RDS or should be on RDS ,were randomly divided into thera- peutic group and control group, Seventeen infants of therapeutic group received Curosurf and then given nasal continuous positive airway presuer （CPAP）. helping breathing and fifteen neonates of control group did not use Curosurf. all of the other supportive treatments were same with both groups. Results （ 1 ） The changes of PaCO2, PaO2, pH in therapeutic group were significently more different than control group （ P 〈 0. 05 ）. （ 2 ） The neonatal complications and the mortality and morbiclity were obviously lower than in control group. （3） The time of using CPAP and the days of in hospital were shorter than in control group （ P 〈 0.05 ）. Conclusions The early treatment with Curosurf for nronates could reduce not only the times in medicines and the time duration of mechanical ventilation, but also money on medicines and the risk of complication, it is improved the quanlity of neonatal live.
