摘要
目的探讨非肿块型与肿块型乳腺癌免疫组织化学指标表达的差异,分析非肿块型乳腺癌的生物学特征。资料与方法回顾性分析19例非肿块型和18例肿块型乳腺癌患者,术后所有病理标本均行免疫组织化学HE染色,测定癌细胞的人表皮生长因子受体-2(HER2)、雌激素受体(ER)、孕激素受体(PR)、Ki-67,比较非肿块型和肿块型各指标表达差异。结果非肿块型乳腺癌中导管原位癌12例,约占63.2%;肿块型乳腺癌中浸润性导管癌12例,约占66.7%。非肿块型和肿块型乳腺癌的HER2、ER、PR表达差异均无统计学意义(P>0.05);而非肿块型乳腺癌Ki-67阳性率低于肿块型乳腺癌,差异有统计学意义(P<0.05)。结论非肿块型乳腺癌的HE染色特征与肿块型乳腺癌存在重叠,两组间Ki-67表达存在差异,证明两者在生物学特性上存在一定差异。
Purpose To explore the expressional differences of immunohistochemical indicators between the non-mass-like and mass-like breast cancers, and to identify the biological characteristics of non-mass-like breast cancer. Material and Methods Various immunohistochemical indicators（HER2, ER, PR, Ki-67） were analyzed in 19 cases nonmass-like cancer and 18 cases mass-like breast cancer retrospectively, and the expressional differences of the two groups were compared. Results 12 cases（63.2%） were diagnosed DCIS in the non-mass-like breast cancer group, but in the mass-like breast cancer group, the majority（12 cases, 66.7%） were invasive cancer. HER2, ER, PR expression had no statistical difference between the two types（P〉0.05）. But the Ki-67 positive rate expressed in non-mass-like breast cancer was lower significantly（P〈0.05）. Conclusion The HE immunohistochemical characteristics of non-mass-like breast cancer are overlapped with that of mass-like breast cancer, but Ki-67 expression has significant difference between the two groups. There are some differences in biological characteristics of these two kinds of breast cancers.
作者
李亚帅
王知力
李晔
何艳
LI Yashuai WANG Zhili LI Ye HE Yan(Department of Ultrasound, Chinese PLA General Hospital, Beijing 100853, China)
出处
《中国医学影像学杂志》
CSCD
北大核心
2016年第12期897-899,902,共4页
Chinese Journal of Medical Imaging
基金
国家自然科学基金(81541130)
首都发展基金(2014-4-5014)
