摘要
目的检测子宫内膜息肉(EP)患者雌激素受体(ER)、孕激素受体(PR)的表达,探索EP形成的原因及机制。方法 40例EP患者作为观察组,40例经病理组织学证实为正常子宫内膜者作为对照组,两组均采用免疫组化方法手术中所取组织的ER、PR表达水平,并进行比较。结果两组增殖期与分泌期ER表达组间比较差异均无统计学意义(P>0.05);观察组增殖期与分泌期PR表达[(3.002±0.752)、(2.845±0.658)分]均低于对照组[(3.545±0.523)、(3.485±0.585)分],差异均具有统计学意义(P<0.05)。结论 ER、PR的异常表达与EP形成存在相关性,特别是PR低表达可能参与了EP形成的病理过程。
Objective To detect expression of estrogen receptor（ER） and progesterone receptor（PR） in endometrial polyps（EP） patients. Methods There were 40 EP patients as observation group, and 40 normal endometrium people certified by Histopathology. ER and PR express level were detected in organizations taken by immunocytochemistry method in both groups and compared. Results Both groups had no statistically significant difference in ER express in proliferative and secretory stage between two groups（P〉0.05）. The observation group had lower ER express in proliferative and secretory stage[（3.002±0.752） and（2.845±0.658） points] than [（3.545±0.523） and（3.485±0.585） points] in control group, and the difference had statistical significance（P〈0.05）. Conclusion Abnormal expression of ER and PR was related to EP formation, and low expression of PR may be involved in pathological process of EP formation.
出处
《中国实用医药》
2016年第35期42-43,共2页
China Practical Medicine
关键词
雌激素受体
孕激素受体
子宫内膜息肉
宫腔镜
Estrogen receptor
Progesterone receptor
Endometrial polyps
Hysteroscopy
