摘要
目的探讨C-myc在宫颈鳞状细胞癌(CSCC)中的表达及临床意义。方法对2014年1月-2016年1月甘肃省人民医院病理科存档的CSCC蜡块102例、宫颈上皮内瘤变(CIN)41例采用免疫组织化学法进行C-myc表达检测,并与随机选取的正常宫颈组织存档蜡块20例作对照。结果 C-myc在CSCC、CIN和宫颈正常组织中的阳性率分别为62.75%、4.88%和0(P<0.05);C-myc在CSCC中的表达水平与FIGO分期、淋巴结转移情况呈正相关(P<0.05),与年龄分布无关(P>0.05)。结论 C-myc参与CSCC的发生发展,能够指导临床早期诊断以及评估CSCC发展程度。
Objective To explore the expression and clinical significance of C-myc in cervical squamous cell carcinoma（ CSCC）.Methods A total of 102 paraffin- embedded CSCC samples and 41 paraffin- embedded cervical intraepithelial neoplasia（ CIN） samples were selected from Department of Pathology in the hospital from January 2014 to January 2016,the expression of C-myc was detected by immunohistochemistry,then the results were compared with 20 normal paraffin-embedded cervical samples who were selected randomly. Results The positive rates of C-myc in CSCC,CIN and normal cervical tissue were 62. 75%,4. 88% and 0. 00%,respectively,the difference was statistically significant（ P〈0. 05）; the expression level of C- myc in CSCC was positively correlated with FIGO stage and lymph node metastasis（ P〈0. 05）,which was not correlated with age distribution（ P〉0. 05）. Conclusion C-myc is involved in occurrence and development of CSCC,and it can guide early clinical diagnosis and assess the development of CSCC.
出处
《中国妇幼保健》
CAS
2017年第2期375-377,共3页
Maternal and Child Health Care of China
基金
国家自然科学基金资助项目(81260387)
关键词
宫颈鳞状细胞癌
C-MYC
表达
Cervical squamous cell carcinoma
C-myc
Expression
