摘要
肾小管酸中毒（RTA）是一类由于近端肾小管HCO3^-重吸收和（或）远端肾小管泌H^＋功能障碍引起的临床综合征。该疾病的致病谱广泛，常见病因包括自身免疫性疾病（如干燥综合征）、慢性肾脏疾病、药物中毒、遗传性疾病等。生化特点以代谢性酸中毒、反常性碱性尿为主。该疾病常累及多个系统和器官，因此其临床表现复杂多变，易发生骨软化症、尿结石、慢性肾功能不全等各种并发症，致残率高。明晰病因并施以针对性治疗，能够明显改善预后。
Renal tubular acidosis （RTA） is a clinical syndrome caused by dysfunction of proximal tubular HCO3^- resorption and/or distal renal tubular H^ ＋ secretion. A var/ety of diseases can induce this disorder, such as autoimmune disease （Sjogren＇s syndrome） , chronic kidney diseases, drug poisoning, genetic diseases, etc. Biochemical examination shows metabolic acidosis and paradoxical alkaline urine. Since various systems or organs are always involved in this disease, the clinical manifestations are complex and diverse. It can lead to serious complications, such as osteomalacia, urinary calculi, renal failure, resulting in high risk of disability. With effective treatment to respective causes, the patients with RTA can get better prognosis.
出处
《国际内分泌代谢杂志》
2017年第1期56-58,共3页
International Journal of Endocrinology and Metabolism
基金
国家自然科学基金资助项目（81471026）
关键词
肾小管酸中毒
干燥综合征
尿结石
Renal tubular acidosis
Sjogren＇s syndrome
Urinary calculi
