摘要
目的:研究紧急避孕药左炔诺孕酮的多晶型现象。方法:通过多种物理(化学)方法对左炔诺孕酮进行多晶型筛选,采用粉末X射线衍射(PXRD)技术对筛选得到的多晶型样品进行表征。结果:左炔诺孕酮具有低溶解性与低渗透性性质,通过多晶型筛选获得左炔诺孕酮的α、β、B 3种晶型。3种晶型样品PXRD图谱的衍射峰位置、衍射峰数量、衍射峰强度、衍射峰几何拓扑等特征均存在明显差异。结论:左炔诺孕酮存在α、β、B 3种晶型,通过PXRD技术可对左炔诺孕酮3种晶型进行鉴别。
Objective： To study polymorphs of Levonorgestrel as emergency contraceptive. Methods： Kinds of physical or chemical methods were used in order to get polymorphs of Levonorgestrel. These polymorphs were characterized by X-ray powder diffraction analysis （PXRD）. Results： Levonorgestrel had nature of low permeability and low solubility. Three crystal forms of Levonorgestrel （form α, form β and form B） were discovered and their PXRD diffraction peaks were different in position, number, intensity and geometric topological characteristics. Conclusion： There are three polymorphism in Levonorgestrel, which include Form α, form β and form B, and the three forms can be identified by PXRD.
出处
《中国计划生育学杂志》
2017年第1期12-14,20,共4页
Chinese Journal of Family Planning
基金
2016年国家重点研发计划(2016YFC1000900)
关键词
左炔诺孕酮
多晶型现象
晶型鉴别
Levonorgestrel
Polymorphism
Useful characterization methods for polymorphs
