摘要
目的:探讨艾司西酞普兰治疗国内惊恐障碍患者的疗效和安全性。方法:应用Meta分析对12项艾司西酞普兰对照研究文献进行再分析,评价其合并效应量大小和综合显著性检验。结果:艾司西酞普兰治疗前后的自身对照显示,艾司西酞普兰治疗惊恐障碍2周后疗效变化显著(Tau2=4.06;95%CI:1.92,2.28;Z=5.90;P<0.01)。艾司西酞普兰与对照药的比较结果表明,艾司西酞普兰2周起效(Tau2=0.42;95%CI:-1.35,-0.43;Z=3.82;P<0.01);但终点疗效与对照药比较差异不显著(Tau2=6.04;95%CI:-0.20,0.05;Z=1.18)。安全性比较发现,艾司西酞普兰的不良反应少于其他抗抑郁剂,但差异不显著。结论:艾司西酞普兰治疗惊恐障碍起效快,安全性好。
Objective： To compare the efficacy and safety of escitalopram with the other antidepressants（as the control） in the treatment of panic disorder（PD）. Methods： Chinese databases up to 2016 were searched,12 related studies of escitalopram and other antidepressants in the treatment of PD were analyzed by Meta-analysis.Results： The significant improvement after treatment of PD by escitalopram was found（Tau2= 4. 06; 95% CI：1. 92,2. 28; Z = 5. 90; P〈0. 01）. Comparison between escitalopram and other antidepressants showed no difference at treatment endpoint（Tau2= 6. 04; 95% CI：- 0. 20,0. 05; Z = 1. 18）; however,escitalopram had quickly relieved symptoms at the second week（Tau2= 0. 42; 95 % CI：- 1. 35,- 0. 43; Z = 3. 82; P〈 0. 01）.Furthermore,it had fewer side effects, but no difference was found compared with other antidepressants.Conclusion： Escitalopram could have similar efficacy and safety with other antidepressants,but have a rapid onset in the treatment of PD.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2017年第2期197-202,共6页
Chinese Journal of New Drugs
