摘要
目的:探讨艾司西酞普兰对广泛性焦虑病人的临床疗效和安全性。方法:随机分为艾司西酞普兰组和氟西汀组,艾司西酞普兰10～20 mg/d,氟西汀10～20 mg/d,疗效采用汉密尔顿焦虑量表(HAMA)评定,不良反应和安全性用TESS和实验室检查评定。观察时间为8周。结果:艾司西酞普兰组有效率76.7%,治愈率50%,氟西汀组有效率73.3%,治愈率43.3%,两组比较差异无显著性(P>0.05)。结论:艾司西酞普兰治疗广泛性焦虑症病人安全有效,疗效和不良反应与氟西汀相似。
Objective：To investigate the clinical efficacy and safety of escitalopram in treating the patients with generalized anxiety.Methods：Sixty patients with generalized anxiety were randomly divided into two groups.The patients in the study group were treated with escitalopram in a dose of 10~20 mg/d and the control group with fluoxetine in a dose of 10~20 mg/d.All the subjects were rated by Hamilton Rating Scale for Anxiety（HAMA）,and Treatment Emergent Symptoms Scale（TESS） at the baseline and the end of 1,2,4,6,8 weeks respectively.Results：The effective rate and the cure rate were 73.3% and 43.3% in fluoxetine group,and those were 76.7% and 50% in escitalopram group respectively at the end of 8 weeks according to the HAMA score with no statistical difference between the two groups.Conclusion：Escitalopram is effective and safe in treating generalized anxiety,which efficacy and adverse reactions are same to fluoxetine.
出处
《现代医药卫生》
2011年第9期1287-1289,共3页
Journal of Modern Medicine & Health
