摘要
目的 :检测血管内皮生长因子(vascular endothelial factor,VEGF)和表皮生长因子(epidermal growth factor receptor,EGFR)在原发性肝癌(primary liver cancer)中的表达状况,研究两者与原发性肝癌的临床生物学行为之间的关系及两者之间的相关性。方法:采用免疫组化SP法检测VEGF、EGFR在63例原发性肝癌中的表达状况。结果:163例原发性肝癌中,VEGF、EGFR的阳性表达率分别为63.5%、50.8%;2 VEGF在原发性肝癌中的阳性表达与Edmondson病理分级、有无门静脉癌栓、肿瘤有无包膜及临床分期相关(P<0.05),而与性别、年龄、AFP水平、HBs Ag状况、有无肝硬化、组织学类型及肿块大小无关(P>0.05);3EGFR在原发性肝癌中的阳性表达与组织学类型、Edmondson病理分级、肿块大小、肿瘤有无包膜相关(P<0.05),而与性别、年龄、AFP水平、HBs Ag状况、有无肝硬化、有无门脉癌栓及临床分期无关(P>0.05);4在原发性肝癌中,VEGF和EGFR的表达关系呈正相关关系。结论:VEGF、EGFR在原发性肝癌的发生、发展过程中起重要作用。
Objective：To investigaee the expressions of VEGF and EGFR and their associations with the clinical biological behavior in primary liver cancer. Methods：The protein expressions of VEGF and EGFR were detected in 63 primary liver cancer by immunohistochemistry streptavidin-perosidase（SP）methods. Results： 1The positive expression rate of VEGF and EGFR was 63.5%and 50.8%,respectively. 2The expression of VEGF was significantly correlated with Edmondson pathologic grade,portal vein tumor thrombus,tumor capsule and clinical stage（P 〈 0.05）,while not with sex,age,AFP level,HBs Ag status,liver cirrhosis,histological type and tumor size（P 〉 0.05）. 3EGFR expression was related to histological type,Edmondson pathologic grade,tumor mass and tumor capsule（P 〈 0.05）. No correlation was found between EGFR expression and sex,age,AFP level,HBs Ag status,liver cirrhosis,portal vein tumor thrombus,clinical stage（P 〉 0.05）. Conclusion：VEGF and EGFR play an important role in the growth and metastasis of primary liver cancer.
作者
高潺潺
吴平平
金潇潇
Gao Chanchan Wu Pingping Jin Xiaoxiao(Department of Oncology, the Affiliated Zhongda Hospital, Southeast University, Nanjing 210009 Department of Oneology , Jiangs u Tumor Zhongda Hospital, Nanjing 210009, China)
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2016年第12期1436-1439,共4页
Journal of Nanjing Medical University(Natural Sciences)
