摘要
目的探讨以左锁骨下动脉内径与主动脉峡部内径之比(LsA/AoIs)作为间接指标在诊断胎儿主动脉缩窄中的应用价值。方法回顾性分析49例产前诊断为主动脉缩窄的胎儿超声心动图资料(79例次)。按不同孕周进行分组(每组病例中包括不同孕周随访复查的病例):组1,24~27周;组2,28~31周;组3,32±35周;组4,36±39周;同时选取与各组孕周匹配的正常胎儿作为对照组,测量各组胎儿左锁骨下动脉内径和主动脉峡部内径,计算二者比值,并与各正常对照组相比较;同时计算不同孕龄组LsA/AoIs的截断值,探索以LSA/AoIs作为间接指标诊断胎儿主动脉缩窄的具体标准。结果①与正常对照组比较,主动脉缩窄组胎儿各孕周左锁骨下动脉内径差异均无统计学意义。组1(1.87±0.42)mm对(1.75±0.25)mm,组2(2.25±0.36)mm对(2.21±0.22)mm,组3(2.74±0.32)mm对(2.90±0.29)mm,组4(2.83±0.28)mm对(3.06±0.30)mm,均P〉0.05];②主动脉缩窄组胎儿的LsA/AoIs较正常组胎儿增大,差异均具有统计学意义[组1(0.88±0.15)对(0.66±0.06),组2(0.85±0.13)对(O.64±0.05),组3(0.94±0.17)对(0.73±0.07),组4(0.94±0.18)对(0.70±0.07),均P〈0.05];③每个孕龄组LsA/AoIS均有一截断值(组1:0.78;组2:0.73;组3:0.83;组4:0.78)。结论LSA/AoIS可作为一种较为实用的间接诊断指标诊断胎儿主动脉缩窄,此比值≥0.8时有一定诊断意义。
Objective To evaluate the diagnostic value of the diameter ratio of left subclavian artery to aortic isthmus (LSA/AoIS) in fetuses with aortic eoarctation (COA). Methods A retrospective study of 79 fetal echoeardiographic data was undergone on 49 COA fetuses. The COA cases were divided into four groups according to different gestational week (cases in each group including follow-up review of different gestational weeks) :group 1,24-27+6 W;group 2,28- 31+6 W;group 3,32- 35+6 W;group 4,36- 39+6 W. The normal fetuses with gestational age matched were also divided into four control groups. The diameter of left subclavian artery (LSA) and aortic isthmus (AoIS) were measured, the ratio of LSA/AoIS of each group were calculated, and the data between the COA and control groups were compared. ROC curve analysis was used for LSA/AoIS to predict the demarcation point of postnatal COA. Results (!) There was no statistic difference in the LSA diameter between COA groups and control groups (P 0.05) :group 1 (1.87±0.42)mm vs (1.75±0.25)mm;group 2 (2.25±0.36)mm vs (2.21 ±0.22)mm; group3 (2.74±0.32)mm vs (2.90 ± 0.29)mm;group 4 (2.83±0.28)mm vs (3.06±0.30)mm;The ratio of LSA/AolS was significantly increased in COA groups than those in control groups:group 1 (0.88 ±0. 15) vs (0.66 ± 0.06) ,group 2 (0.85 ± 0.13) vs (0.64 ± 0.05) ,group 3 (0.94 ± 0.17) vs (0.73 ± 0.07), group 4 (0.94 ± 0. 18) vs (0.70 ± 0.07), the difference was statistically significant ( P 〈0.05) ; (2)The cut- off value of LSA/AoIS ratio were 0. 78,0.73,0.83,0.78 in each group, respectively. Conclusions The ratio of LSA/AoIS can be used as a useful eehoeardiographic parameter which suggest the presence of aortic coarctation. This ratio-0.8 may have a certain clianostie significance.
出处
《中华超声影像学杂志》
CSCD
北大核心
2017年第1期21-24,共4页
Chinese Journal of Ultrasonography
基金
首都医科大学基础-临床科研合作基金(16JL39)
北京市重点实验室(BZ0308)
心血管疾病精准医学北京实验室(116211)