摘要
目的 探讨胺碘酮联合美托洛尔对老年冠心病合并心律失常患者超声指标及预后的影响.方法 选择2012年5月-2015年1月老年冠心病合并心律失常患者80例为研究对象,根据入院时间先后顺序随机分为观察组42例和对照组38例,观察组患者接受胺碘酮联合美托洛尔治疗,对照组患者接受胺碘酮治疗,比较两组患者心绞痛的发作情况、心功能情况、血清炎性因子含量、治疗效率.结果 临床疗效：观察组显效有效率92.86％明显高于对照组76.32％ （χ^2=4.281,p〈0.05）;心绞痛发作情况：观察组心绞痛发作次数、硝酸甘油服用数量均明显低于对照组（1.58±0.25 vs 2.29±0.42,1.79±0.31 vs 2.42±0.48）（t=9.290,7.039,p〈0.05）;超声指标：观察组左心室舒张末期内径（LVDD）、左心室收缩末内径（LVSD）均明显低于对照组（52.58±6.15vs 57.91±6.62,40.59±4.75 vs 45.88±5.14）mm（t=3.733,4.784,p〈0.05）,左心室射血分数（LVEF）、左室短轴缩短率（LVSF）均明显高于对照组（54.14±6.24vs 48.42±5.56,53.49±5.91 vs 49.71±4.94）％（t=4.310,3.086,p〈0.05）;炎性因子：观察组血清中C反应蛋白（CRP）、肿瘤坏死因子-α （TNF-α）、白细胞介素-6（IL-6）的含量均明显低于对照组[4.21±0.65 vs 6.35±0.85）mg/L,（0.52±0.15 vs 0.87±0.32）ng/L,（6.49±0.78vs 8.35±1.02）ng/L]（t=12.718,6.361,9.212,p〈0.05）.结论 胺碘酮联合美托洛尔能够减少心绞痛的发作,改善心功能,减轻炎症反应程度,提高治疗效果.
Objective To study the effect of amiodarone combined with metoprolol on echocardiography and prognosis of elderly patients with coronary heart arrhythmia. Methods 80 cases elderly patients with coronary heart disease and arrhythmias from May 2012 - January 2015 were randomly divided into observation group 42 cases and control group 38 cases, the observation group received amiodarone combined with metoprolol treatment, the control group of patients treated with amiodarone. Then angina pectofis, heart function, serum inflammatory factors contents, therapy effect were compared between two groups. Results Clinical curative effect： observation group efficient 92.86% aere significantly higher than the control group 76.32% （χ^2=4.281, p 〈0.05）; Angina pectoris： observation group anginal attacks and nitroglycerin on quantity were significantly lower than the control group （1.58 ± 0.25 vs 2.29 ± 0.42, 1.79 ± 0.31 vs 2.42 ± 0.48）（t=9.290, 7.039, p〈0.05）; Ultrasonic indicators： observation group LVDD, LVSD were significantly lower than at control group （52.58 ± 6.15 vs 57.91 ± 6.62, 40.59 ± 4.75 vs 45.88 ± 5.14）ram（t=3.733, 4.784, p〈0.05）, LVEF, LVSF were significantly higher than the control group （54.14 ± 6.24 vs 48.42 ± 5.56, 53.49 ± 5.91 vs 49.71 ± 4.94）% （t=4.310, 3.086, p〈0.05）; Inflammatory factor： observation group serum CRP,TNF-α, IL-6 levels were significantly lower than the control group [（4.21 ± 0.65 vs 6.35 ± 0.85）mg/L, （0.52 ± 0.15 vs 0.87 ± 0.32） ng/L, （6.49 ± 0.78 vs 8.35 ± 1.02） ng/L]（ t=12.718, 6.361, 9.212, p〈0.05）. Conclusions Amiodarone Combined with Metoprolol can reduce angina and improve cardiac function, reduce inflammation degree, and improve therapy effect.
出处
《临床心电学杂志》
2016年第6期408-412,共5页
Journal of Clinical Electrocardiology
关键词
冠心病
心律失常
胺碘酮
美托洛尔
超声指标
炎症反应
Coronary heart disease
Arrhythmia
Amiodarone
Metoprolol
Ultrasonic indicators
Inflammation
