摘要
目的:观察依折麦布辛伐他汀片对冠心病患者颈动脉粥样硬化干预作用的疗效。方法:选取确诊为冠心病同时存在不同程度颈动脉粥样硬化的患者110例,按随机数字表法分为观察组和对照组,观察组58例,给予依折麦布辛伐他汀片30 mg 1/晚,同时根据需要给予其他必要的正规抗血小板、降压等治疗。对照组52例,给予辛伐他汀片20 mg 1/晚,并根据病情需要予以适当的常规治疗。疗程6个月,观察治疗前后血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及颈动脉内膜-中层厚度(IMT)、颈动脉内膜斑块面积及斑块积分的变化。结果:治疗后观察组与对照组患者总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)均明显降低,高密度脂蛋白胆固醇(HDL-C)明显升高,且观察组较对照组更明显,组间差异有统计学意义(P<0.05);两组患者治疗后斑块面积、颈总动脉内膜-中层厚度(IMT)及斑块积分显著减少,且观察组变化较对照更加明显,差异有统计学意义(P<0.05);两组均未出现黄疸、肝功能损害、横纹肌溶解等严重病例。结论:依折麦布辛伐他汀片较单独应用辛伐他汀片组在逆转颈动脉粥样硬化及调脂方面效果更加显著且安全性更高。
Objective To observe intervention effect of ezetimibe and simvastatin tables on carotid artery atherosclerosis in patients with coronary heart disease（ CHD）. Method 110 patients were slelected for CHD and confirmed the existence the different degree of carotid atherosclerosis. According to the random number group table methd,they were divided into Observation group（ n = 58） and control group（ n = 58）. Observation group 58 cases were received ezetimibe and simvastatin tablets 30 mg qn,besides,according to the need to give other necessary fomal antiplatelet、antihypertensive treatments. Control group 52 cases were received simvastatin tablets 20 mg qn. meanwhile,given the conventional treatment properly,All patients were received therapy six months. The levels of serum total cholesterol（ TC） 、triglgceride（ TG） 、low-density lipoprotein cholesterol（ LDL-C） 、high density lipoprotern cholesterol（ HDL-C） and carotid intima-middle thickness（ IMT） 、carotid intima plaque area、plaque score were compared between two groups in pretherapy and post-treatment. Results Compared to pretherapy,the two groups levels of TC、TG、LDL-C were lower but the level of HDL-C was higher. The change of observation groups was more obvious than the control group,the difference was statistically significant（ P〈0. 05）. compared the groups after treatment,the levels of plague area、IMT、plaque score were lower. The change of observation group was more obvious than the control group,the difference was statistically significant（ P〈0. 05）. Conclusion Ezetimibe and simvastatin ware more significant and higher security than simvastatin in reversing carotid atherosclerosis and improving blood lipid.
出处
《吉林医学》
CAS
2017年第1期23-25,共3页
Jilin Medical Journal
基金
新疆维吾尔自治区自然科学基金资助项目[项目编号:2012211C124]
关键词
依折麦布辛伐他汀片
冠心病
颈动脉粥样硬化
Ezetimibe and simvastatin tablets
Coronary heart disease
Carotid atherosclerosis
