摘要
目的探讨来氟米特联合甲氨蝶呤治疗类风湿关节炎的疗效。方法将2010年1月～2012年1月我院治疗的52例类风湿关节炎患者,根据随机数字表法随机分为联合组和对照组各26例,其中对照组给予甲氨蝶呤,联合组在对照组基础上同时给予来氟米特治疗,比较两组的疗效、关节损害严重病例情况以及两组实验室检查指标ESR、CRP治疗前后的变化。结果联合组的总有效率达92.3%,明显高于对照组(P<0.05)。联合组与对照组治疗前关节损害严重病例分别为18例,17例,治疗3个月后,联合组与对照组关节损害严重病例均较治疗前明显减少,分别为10例,13例。且两组患者的ESR、CRP水平治疗后均较治疗前明显降低,且联合组降低更明显(P<0.05)。结论来氟米特联合甲氨蝶呤治疗类风湿关节炎疗效显著,能明显改善临床症状,安全性好,值得推广使用。
Objective To investigate the efficacy of leflunomide and methotrexate treatment rheumatoid arthritis. Methods From January 2010 January 2012,52 cases rheumatoid arthritis patients according to the random number table were ran- domly divided into the combined group and the control group,each group 30 cases, the control group was given methotrex- ate,the combined group on the basis of the control group was given [eflunomide treatment, the efficacy and joint severe damage cases,and laboratory parameters ESR of CRP changes before and after treatment were compared between two groups. Results The total effective rate of the combined group was 92.3%,and it was significantly higher than the control group （P 〈 0.05）. Reduced joint severe damage cases of joint group and control group before treatment were 18 cases, 17 cases, after treatment for 3 months,joint severe damage cases of the joint group and the control group were 10 cases, 13 cases, respectively.And ESR, CRP level of two groups reduced than before treatment significantly, and the joint group decreased more significantly （P 〈 0.05）. Conclusion The efficacy of leflunomide and methotrexate treatment rheumatoid arthritis is significantly, can significantly improve the clinical symptoms, security is good, and it is worth of promoting.
出处
《中国现代医生》
2012年第21期64-65,共2页
China Modern Doctor
