摘要
目的:探讨多发性硬化(multiple sclerosis,MS)患者外周静脉血血清钙结合蛋白复合物(S100A_8/A_9)、Toll-样受体4(Toll-like receptor 4,TLR4)和基质金属酶蛋白2(matrix metalloproteinase-2,MMP-2)表达水平的变化。方法:选取MS患者16例作为MS组,健康体检者16例作为对照组。采用蛋白芯片检测法对血清样本进行检测,定量分析血清S100A_8/A_9、TLR4和MMP-2表达水平的变化。结果:MS组血清S100A_8/A_9、TLR4和MMP-2水平均高于对照组(P<0.01);MS组患者血清中上述3个指标具有明显相关性(P<0.05)。结论:MS患者血清S100A_8/A_9、TLR4和MMP-2表达上调,联合检测三者可能有助于临床MS疾病活动状态的判断。
Objective ： T o investigate the clinical significance of S10〇Ag/A9 , T oll-like receptor 4 （T L R 4 ） and matrixmetalloproteinase （M M P -2） levels in peripheral venous serum of patients with multiple sclerosis （M S ）. Methods： Totally 16cases of M S patients were selected as M S group, and 16 cases of healthy people as control group. T h e serum samples weredetected by protein chip detection method to quantificationally analyze the changes of serum SlOOAg/Ag,T L R 4 and M M P-2levels. Results： T h e serum of S100Ag/A9 , T L R 4 and M M P-2 levels in M S group were significantly higher than which incontrol group （P〈C0. 0 1 ） ; T h e three indicators in M S patients showed significant correlations （P〈C0. 0 5 ）. Conclusions： T heexpression of SlOOAg/Ag,T L R 4 and M M P-2 in the serum of patients with clinical M S is up-regulated, suggesting that theymight be involved in the pathogenesis of MS. Combined detection of serum SlOOAg/Ag,T L R 4 and M M P-2 levels may providea new way of thinking for the diagnosis, treatment and judgment of state in clinical MS.
作者
刘大进
吴明凤
余浩
张振中
马丽
姚瑞芹
L IU D a-jin W U M ing-feng Y U H ao ZHANG Zhen-zhong M A L i YA O Rui-qin(Research Center of Neurobiology Xuzhou Medical University, Xuzhou 221004, Jiangsu, China)
出处
《中国临床医学》
2016年第6期801-804,共4页
Chinese Journal of Clinical Medicine
基金
国家自然科学基金(81271345)
江苏省自然科学基金(BK20131132)
江苏省2014年度高校"青蓝工程"中青年学术带头人资助项目
江苏省高校自然科学研究面上项目(15KJB180018
15KJB310023)~~
