摘要
质量控制是保证中药疗效和安全性的前提,而中药远志在质量控制方面面临以下几个问题:1药用品种在历代本草与现代药典中的记载不尽相同;2远志的产地不断变迁,导致其道地产区需进一步明确;3传统认为远志"服之令人闷"与其木心有关,生远志可"戟人咽喉",但对引起上述副作用的化学成分认识不深。针对以上问题,通过查阅历代本草、现代专著、文献等资料,对资料中记载的远志药用品种进行梳理,发现其多个品种在历代均有使用,且山西为现今远志的道地产区;通过考证,认为远志"服之令人闷"可能与皂苷类成分有关、"戟人咽喉"可能是由药材中的皂苷类、甲苯、生物碱等类成分共同引起,并需经炮制来减缓,为远志的炮制减毒研究提供了理论依据。
Quality control is the premise for traditional Chinese medicine efficacy and safety, but there are some problems in quality control of Polygalae Radix. The records of the modem pharmacopoeias for its medicinal species are not consistent with them in the ancient herbal books. Habitats of Polygala tenuifolia are endlessly changed in the ancient herbal books, which leads to an unclear genuine producing area. According to the traditional medicine theories, the reason why people feel dysphoria after taking P. tenuifolia is xylem and P. tenuifolia is bad for the throat without processing. However, the chemical composition that causes these side effects is not very clear. This paper reviewed the medicinal species, genuine producing area and the reasons for side effects ofP. tenuifolia by consulting ancient herbal books, monographs, and literature. In the past, there are many other polygala plants used widely in all over the country. Shanxi province has become the genuine habitat for P. tenuifolia. The reason why people feel dysphoria after taking P. tenuifolia is saponins. All saponins, methylbenzene, and alkaloids cause these side effects for throat, but processing can reduce it. This review on processing aspect can provide evidence for reducing toxicity ofP. tenuifolia.
作者
蒲雅洁
王丹丹
张福生
秦雪梅
詹志来
PU Ya-jie WANG Dan-dan ZHANG Fu-sheng QIN Xue-mei ZHAN Zhi-lai(Modem Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China National Resource Center for Chinese Medical Sciences, Beijing 100700, China)
出处
《中草药》
CAS
CSCD
北大核心
2017年第1期211-218,共8页
Chinese Traditional and Herbal Drugs
基金
山西省应用基础研究项目(201601D011064)
国家中药标准化项目(ZYBZH-Y-JIN-34)
中央本级重大增减支项目(2010081070)
地产中药功效物质研究与利用山西省重点实验室(201605D111004)
山西省科技创新重点团队(201605D131045-18)
关键词
远志
基原
产地
炮制
本草考证
Polygalae Radix
origins
habitats
processing
herbal textual research
