摘要
目的了解正规外用糖皮质激素治疗的湿疹患儿体格生长情况。方法纳入初诊为湿疹的足月婴儿115例,正规外用糖皮质激素治疗;定期评估患儿湿疹情况并进行生长监测和评估。结果 115例患儿出生时以及接受治疗6个月时的按年龄体质量Z评分(WAZ)和按年龄身长Z评分(LAZ)均高于世界卫生组织(WHO)儿童生长标准;而初诊时、接受治疗3个月时的LAZ均低于WHO儿童生长标准。湿疹患儿的体质量、身长,从出生至初诊时的生长速度均低于WHO生长标准,而接受治疗后3至6个月时的生长速度均高于WHO儿童生长标准。出生至初诊、初诊至接受治疗3个月,以及治疗后3至6个月,三个时间段比较,WAZ和LAZ增长值的差异均有统计学意义(P均<0.001)。结论湿疹患儿在患病初期,症状未控制时体格生长呈减速生长,治疗后则呈现加速。提示正规外用糖皮质激素治疗湿疹对患儿体格生长无不良影响,且随疾病控制有利于婴儿体格生长恢复。
Objective To explore the physical growth in infants with eczema who treated with regular use of glucocorticoid. Methods A total of 115 full-term infants newly diagnosed with eczema were included in this study and treated with topical glucocorticoids regularly. The severity of eczema was assessed and anthropometric indices were measured regularly. Results Both weight for age （WAZ） and length for age （LAZ） at birth and 6-month-old were higher than those of World Health Organization （WHO） child growth standards. However, the LAZ at diagnosis and 3 months after treatment were lower than that of WHO child growth standards. The weight, length, and the growth rate from birth to the time of diagnosis were all lower than those of WHO child growth standards. While the growth rate after treatment for 3 to 6 months was higher than that of WHO child growth standards. The increases of WAZ and LAZ were significantly different among three periods： at birth to diagnose, at diagnosis to 3 months after treatment, and 3 months to 6 months after treatment （P〈0.001）. Conclusion In the early stage of eczema, the growth rate was decreased when the symptoms were not controlled. However, after treatment, the growth rate was increased. It is suggested that treatment of regular topical glucocorticoids has no adverse effects on growth of eczema infants, and also is beneficial to the catch-up growth of infants.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2017年第1期1-4,共4页
Journal of Clinical Pediatrics
关键词
湿疹
婴儿期
体格生长
eczema
infancy stage
physical growth
