摘要
目的探讨骨质疏松高危老年人群骨生化代谢与骨质疏松的关系。方法从社区65岁以上人群健康体检中收集一般资料,应用Cockcroft公式与亚洲人骨质疏松自我筛查工具(OSTA)筛查出内生肌酐清除率轻度减退伴骨质疏松高危人群。应用双能X线吸收仪(DXA)测定左股骨颈骨密度值(LFN BMD),同时测定血生化指标及骨生化、代谢转换指标。结果共筛选出236例骨质疏松高危老年人群,平均年龄为(77.40±5.46)岁。logistic多元回归分析显示OSTA指数、血清25羟维生素D3[25(OH)VitD_3]与骨质疏松呈负相关(OR=0.08,OR=0.65),甲状旁腺激素(PTH)与骨质疏松呈正相关(OR=1.54)。结论 OSTA指数适合运用在社区骨质疏松高危老年人群的筛查工作中,上述人群普遍存在25(OH)VitD_3缺乏,在上述人群中适当补充活性维生素D3和钙剂可延缓骨质疏松的发生。
Objective To explore the relationship between osteoporosis and biochemical marks of bone metabolism in aged people with high risk of osteoporosis. Methods General information of the aged people older than 65 were collected from the health examinations. Coekcroft formula and OSTA index were used to screen high risk population of osteoporosis combined with slight decrease of endogenous creatinine clearance rate. The left femoral neck bone mineral density was detected by dual-energy X ray absorptiometry （ DXA）. Meanwhile, blood biochemical indicators, biochemical markers of bone metabolism was detected. Results A total of 236 high risk elderly patients with osteoporosis with the average age of 77.40 ± 5.46 years were detected. Logistic regression analysis showed that OSTA and 25 （ OH ） VitD3 were negative correlation with osteoporosis （ OR = 0. 08, OR = 0. 65 ）. The level of PTH was positive correlation with osteoporosis （ OR = 1. 54 ）. Conclusion OSTA index is suitable for screening high risk elderly patients with osteoporosis. 25 （OH） VitD3 insufficiency is highly prevalent in this population. Appropriate supplementary of active Vitamin D and calcium is important to the above crowd to reduce the risk of osteoporosis.
出处
《上海预防医学》
CAS
2016年第12期871-874,共4页
Shanghai Journal of Preventive Medicine
基金
上海市黄浦区卫生和计划生育委员会科研基金项目(HKW201539)
关键词
骨代谢生化指标
骨质疏松
内生肌酐清除率
OSTA指数
老年人
biochemical marks of bone metabolism
clearance rate
OSTA index
Aged population osteoporosis
endogenous creatinine
