摘要
目的应用倾向指数法比较补肾活髓颗粒联合西药治疗与单纯西药治疗慢性再生障碍性贫血的临床疗效。方法选择慢性再生障碍性贫血患者236例,随机分为治疗组158例和对照组78例。对照组给予口服司坦唑醇片每次2~4 mg,每日3次;环孢菌素软胶囊每次75 mg,每日2次。治疗组在对照组治疗基础上给予补肾活髓颗粒,每日1剂,分两次口服。两组均治疗6个月。应用倾向指数匹配法对两组患者基线资料进行匹配,对匹配前后两组临床疗效和匹配后、治疗前后两组患者的血红蛋白(HGB)、白细胞(WBC)及血小板(PLT)水平进行比较。结果两组各有76例成功匹配。匹配前两组临床疗效比较:对照组基本治愈16例,缓解14例,明显进步18例,总有效率61.54%;治疗组分别为50例、36例、34例及75.95%,两组比较差异无统计学意义(χ~2=6.71,P=0.08)。匹配后两组临床疗效比较:对照组基本治愈16例,缓解14例,明显进步17例,总有效率61.84%;治疗组分别为12例、18例、17例及61.84%,两组比较差异无统计学意义(χ~2=1.07,P=0.78)。匹配后两组患者治疗后HGB、WBC及PLT较治疗前均明显升高(P<0.01),治疗组治疗后HGB和PLT均明显高于对照组(P<0.05)。结论补肾活髓颗粒联合西药治疗慢性再生障碍性贫血在改善HGB及PLT方面优于单纯西药。
Objective To compare the clinical effect between Bushen Huosui Granules（ 补肾活髓颗粒） combined with western medicine and western medicine alone in treating chronic aplastic anemia（ CAA） adopting propensity score method. Methods Totally 236 CAA patients were chosen and randomized into treatment group（ 158cases） and control group（ 78 cases）. The control group was given Stanozolol Tablet 2- 4 mg each time,3 times every day,and Cyclosporin soft capsule 75 mg each time,2 times every day. In addition to the treatment of the control group,Bushen Huosui Granules was given to the treatment group,1 dose every day,twice orally. Both groups were treated for 6 months. Patients＇ baseline data in both groups were matched by propensity index matching method. The clinical effect in both groups before and after match was compared. Patients＇ hemoglobin（ HGB）,white blood cell（ WBC） and platelets（ PLT） levels in both groups were compared after match,before and after treatment. Results Both groups had 76 cases matched successfully. As for the comparison of the clinical effect in both groups before match,16 cases got basic cure in the control group,with 14 cases relieved and 18 cases significantly improved. The total effective rate was 61. 54%,while in the treatment group,the corresponding numbers were 50 cases,36 cases,34 cases and 75. 95%. The difference was not significant（ χ^2= 6. 71,P = 0. 08）. As for the comparison of the clinical effect in both groups after match,16 cases got basic cure in the control group,with 14 cases relieved and 17 cases significantly improved. The total effective rate was 61. 84%. while in the treatment group,the corresponding numbers were 12 cases,18 cases,17 cases and 61. 84%. The difference was not significant（ χ^2= 1. 07,P = 0. 78）. After match and after treatment,patients＇ HGB,WBC and PLT in both groups increased（ P 〈0. 01）. After treatment,HGB and PLT in the treatment group was much higher than those in the control group（ P〈0. 05）. Conclu
出处
《中医杂志》
CSCD
北大核心
2017年第1期42-45,共4页
Journal of Traditional Chinese Medicine
基金
山东省自然科学基金(ZR2014AQ020)
山东省科技发展计划(2012YD19013)
山东省中医药科技发展计划(2013-244)
