摘要
目的:评价培元涤痰开郁方早期干预中风后抑郁(PSD)发生的临床疗效并探讨其可能机制。方法:采用随机法将100例患者分为对照组和干预组,每组50例。对照组采用一般治疗,干预组在其基础上加用中药汤剂(培元涤痰开郁方)口服,1剂/d,疗程共28 d;两组均于干预前、干预28 d进行汉密尔顿抑郁量表(HAMD)评分、神经功能缺损评分(NIHSS)以评价PSD发生率及神经功能改善的临床疗效,并于治疗前后检测血清hs-CRP含量。结果:干预组PSD发生率18%,对照组发生率40%,二者差异显著(P<0.05);NIHSS临床疗效评定,干预组有效率90%,对照组有效率72%,差异显著(P<0.05);干预组血清hs-CRP含量明显低于对照组,差异有统计学意义(P<0.05)。结论:急性脑梗死患者早期给予培元涤痰开郁方可显著降低PSD发病率,改善患者神经功能缺损,改善生活能力,提高生存质量。其机制可能与拮抗炎症反应有关。
Objective ： To evaluate the effect of treatment through Prescription of Invigoration and Clearing Phlegm and Expelling Stagnation on early stage of post - stroke depression （PSD） and investigate its possible mechanism. Methods ： We randomly divided 100 patients into control group and intervention group with 50 cases in each group. The control group was treated by general treatment and the intervention group with Chinese herbal medicine decoction （Invigoration and Clearing Phlegm and Expelling Stagnation Prescription） on traditional method,one dose for each day by 28 days. In two groups before and after 28 days of treatment ,Hamilton Depression Scale （HAMD） and National Institute of Health stroke scale （blIHSS） were used to evaluate PSD occurrence and clinical effect on nerve function improvement and then we detected Hs - CRP content before and after treatment. Results ：The incidence of depression in intervention group was 18% and that in control group was 40%. There was obvious difference between the two （P 〈 0. 05）. NIHSS：The effective rate was 90% for intervention group and 72% for control group and there was obvious difference between the two （P 〈 0. 05）. The content of serum hs - CRP in intervention group was significantly lower than that in control group and there was statistical significance on difference （P 〈 0. 05 ）. Conclusion： Early treatment through Invigoration and Clearing Phlegm and Expelling Stagnation Prescription can significantly reduce the incidence of PSD on patients with acute cerebral infarction and improve their neurological function so as to improve the quality of their lives. The mechanism may be related to inflammatory response.
出处
《辽宁中医杂志》
CAS
北大核心
2016年第12期2552-2554,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
河南省中医药科学研究专项课题(2013ZYO1013)
关键词
中风后抑郁
培元涤痰开郁方
干预
临床研究
post - stroke depression
Prescription of Invigoration and Clearing Phlegm and Expelling Stagnation
intervention
clinical research
