摘要
REGγ(PSME3,proteasome activator complex subunit 3)是20S蛋白酶体的一种重要激活因子,REGγ-蛋白酶体系统可以非泛素和非ATP依赖方式介导多种重要蛋白降解。研究发现,REGγ以降解不同底物蛋白的方式参与肿瘤的进程、免疫反应、神经性疾病等系列生理病理过程。REGγ的表达可被不同的信号刺激诱导。翻译后修饰也可调控REGγ蛋白的活性,如REGγ的SUMO修饰和乙酰化修饰,均对其降解底物的功能至关重要。因此,REGγ是一个受多水平调控、具多种功能的细胞核内蛋白。本文较系统地综述了REGγ研究的最新进展,阐述了REGγ在许多生理病理过程中的重要作用及其机理。
REGγ（PSME3, proteasome activator complex subunit 3）, as an important 20S proteasome activator, was involved in degrading many important proteins in ubiquitin and ATP independent manner. Recent study showed that REGγ was also involved in series of physiological and pathological process including tumor progression, immune response, neurological disease, etc. It also showed that REGγ could be induced by different stimuli. Posttranslational modifications can regulate REGγ activity. For example, sumoylation and acetylation are critical for the degradation ability of REGγ. Therefore, REG）, is a multifunctional protein which mainly was localized in the nucleus. This paper systematically describes the recent studies of REGγand discusses the important role and its mechanism in physiological and pathological process.
出处
《生命的化学》
CAS
CSCD
2016年第6期950-954,共5页
Chemistry of Life
基金
上海市科委项目(14430712100)
