摘要
目的:研究慢性心功能不全患者N末端脑钠肽前体(NT-proBNP)和心功能状态在肾小球滤过率(GFR)不同范围内的相关性。方法:连续选择200例慢性心功能不全患者,在病情稳定情况下检测NT-proBNP、血清肌酐水平,评价纽约心功能分级(NYHA),计算GFR。结果:NT-proBNP和NYHA随GFR降低而增加,左室射血分数(LVEF)随GFR降低而降低(均P<0.05);左室舒张末期内径(LVEDd)在不同范围GFR内差异无统计学意义。在GFR水平>45ml/min时,NT-proBNP与NYHA呈正相关,与LVEF呈负相关,与LVEDd无明显相关;在GFR水平<45ml/min时,NT-proBNP与NYHA、LVEF和LVEDd均无明显相关性。结论:慢性心功能不全患者NT-proBNP和心功能状态的关系需考虑不同的肾小球滤过率范围。
Objective：To study the relationship between NT-proBNP and heart functions in patients with chronic heart failure under different levels of glomerular filtration rate（GFR）.Method：A total of 120 consecutives was enrolled,serum NT-proBNP and creatinine levels were measured,New York Heart Association（NYHA）classes was evaluated,and creatinine clearance rate（GFR）was calculated.Result：NT-proBNP and NYHA were higher as GFR was lowing,LVEF was lowing as GFR was lowing（P〈0.05）,LVEDd was no statistical differences in different GFR ranges.NT-proBNP was positive with NYHA and negative with LVEF when GFR45 ml/min,while,NT-proBNP was non-related to LVEDd.NT-proBNP and NYHA,LVEF,LVEDd were no correlation when GFR 〈45 ml/min.Conclusion：The relationship between NT-proBNP and heart functions in patients with chronic heart failure should consider different levels of glomerular filtration rate.
作者
王宏
WANG Hong(The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510000, China)
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2016年第12期1247-1249,共3页
Journal of Clinical Cardiology
