摘要
目的综合评价XRCC1 Arg280His多态与肺癌易感性的关系。方法检索中国学术期刊文献数据库和Pubmed,查找有关XRCC1 Arg280His多态与肺癌易感性的关系的病例对照研究,并用Meta分析的方法分析XRCC1 Arg280His多态与肺癌易感性的关系,然后进行亚组分析、敏感性分析和文献的发表偏倚检验。结果本次Meta分析共纳入14篇文献,累计病例数5 711例,对照6 202例,显性模型下His/His＋Arg/His基因型相对于Arg/Arg基因型的OR值为0.97,95%可信区间为0.78-1.22,无统计学意义关系。结论 XRCC1 Arg280His多态与肺癌易感性无统计学意义关系。
Objective To evaluate the association between XRCC1 Arg280 His and lung cancer susceptibility. Methods To collect the reports of case-control studies on the association between XRCC1 Arg280 His and lung cancer susceptibility,we searched CNKI and Pubmed,then evaluated the association of XRCC1 Arg280 His and lung cancer susceptibility by Meta analysis. Then we performed subgroup analysis and sensitivity analysis and publication bias test. Results There were 14 studies with 5 711 cases and 6 202 controls enrolled in this Meta-analysis. The pooled OR of His/His ＋ Arg/His genotype compared to Arg/Arg genotype under dominant model was0. 97 without statistically significant association（ 95% CI： 0. 78-1. 22）. Conclusion The XRCC1 Arg280 His polymorphism was not statistically significantly associated with the lung cancer susceptibility.
出处
《首都医科大学学报》
CAS
北大核心
2016年第6期758-762,共5页
Journal of Capital Medical University
基金
国家自然科学基金青年科学基金项目(81101773)
北京市自然科学基金(7132106)
首都医科大学基础-临床科研合作基金(14JL25
16JL67)资助~~
