摘要
目的观察地佐辛注射液与舒芬太尼注射液对小儿全麻术后的镇痛效果及安全性。方法 78例在全麻下择期进行疝囊结扎手术患儿,随机分为对照组39例与试验组39例。对照组静脉注射枸橼酸舒芬太尼注射液0.5~1.0μg·kg^(-1)+地塞米松注射液0.1~0.2 mg·kg^(-1);试验组静脉注射地佐辛注射液0.15~0.2 mg·kg^(-1)+地塞米松注射液0.1~0.2 mg·kg^(-1)。比较2组患儿的临床疗效、治疗前后血清超敏C-反应蛋白(hs-CRP)、肌酸激酶同工酶(CK-MB)水平,以及药物不良反应发生情况。结果治疗后,对照组的总有效率为76.92%(30/39例),试验组为94.87%(37/39例),差异有统计学意义(P<0.05)。术后24,72 h对照组血清hs-CRP水平分别为(37.29±3.98),(97.29±10.27)mg·L^(-1),试验组分别为(24.29±2.58),(90.29±10.18)mg·L^(-1)(P<0.05)。术后120 h,对照组和试验组血清hs-CRP水平分别为(19.29±2.10),(22.18±2.37)mg·L^(-1)(P<0.05)。术后各时间段CK-MB水平差异无统计学意义(P>0.05)。试验组出现恶心呕吐1例,皮肤瘙痒1例,嗜睡1例,药物不良反应发生率为7.69%(3/39例);对照组出现恶心呕吐2例,皮肤瘙痒2例,嗜睡1例,尿潴留1例,药物不良反应发生率为15.38%(6/39例),2组药物不良反应发生率比较,差异无统计学意义(P>0.05)。结论与舒芬太尼注射液相比,地佐辛注射液对小儿全麻术后镇痛的临床疗效显著,安全性相似。
Objective To evaluate the efficacy injection and sufentanil injection in the treatment sia of patients with general anesthesia. Methods and safety of dezocine of postoperative analge- A total of 78 cases of children under ligation of hernial sac by general anesthesia were divided into control group and treatment group, with 39 cases in each group. Patients in control group were given sufentanil citrate injection 0. 5 - 1.0 μg·kg^-1 ± dexamethasone injection 0. 1 - 0. 2 mg·kg^-1 by intrave- nous drip, and patients in treatment group received dezocine injection 0. 15 -0.2 mg·kg^-1 ± dexamethasone injection 0. 1 -0. 2 mg·kg^-1 by intravenous drip. The clinical efficacy, high -sensitivity C -reactive protein （hs- CRP）, creatine kinase isoenzyme and adverse drug reactions were compared between the two groups. Results The total effective rates in treatment group and control group were 94. 87% （37/39 cases ）, 76. 92% （ 30/39 cases ）, with significant difference （P 〈 0. 05 ）. The levels of serum hs - CRP of 24, 72 h in control group were （37.29 ± 3.98 ）, （97.29 ± 10. 27 ） mg·L^-1, had significant difference with those in treatment group, which were （24. 29±2.58）, （90.29 ±10. 18） mg·L^-1（P 〈0.05 ）. The serum levels ofhs-CRP in 120 h in control group and treatment group were （ 19.29 ± 2. 10 ）, （ 22. 18 ± 2. 37 ） mg·L^-1 （ P 〈 0. 05 ）. The creatine kinase isoenzyme levels had no significant difference between two groups（P 〉0. 05 ）. In treatment group, there were 1 case of nausea and vomiting, 1 case of skin itching, 1 case of somnolence, the incidence rate of adverse drug reactions was 7. 69% （3/39 cases）. There were 2 cases of nausea and vomiting, 2 cases of skin itching, 1 case of lethargy, 1 case of urinary retention in control group, the incidence rate of adverse drug reactions was 15.38% （6/39 cases, P 〉 0. 05 ）. Conclusion Dezocine injection and sufentanil injection have similar safety in the treatment of postoperative analgesia in p
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2016年第24期2253-2256,共4页
The Chinese Journal of Clinical Pharmacology
基金
铜仁市科技计划基金资助项目[铜市科研(2014年)77-13号]
关键词
地佐辛注射液
舒芬太尼注射液
小儿全麻术后镇痛
dezocine injection
sufentanil injection
analgesia after general anesthesia in children
