摘要
目的探讨脑卒中TFGBR2基因多肽性和患者动态血压相关指标的关系。方法选取2014年6月至2015年6月该院收治的急性脑卒中患者60例,其中脑出血患者32例(脑出血组),脑梗死患者28例(脑梗死组);另选取60例体检健康者为对照组。采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)法检测患者TGFBR2基因rs6785358片段多态性,所有患者均行动态血压检测,分析患者TGFBR2基因多态性与脑卒中动态血压的关系。结果脑出血和脑梗死患者A/A基因型均占50.0%,高于对照组,差异均有统计学意义(P<0.05);对照组患者G/G基因型比例(60.0%)高于脑卒中患者,差异有统计学意义(P<0.05);有高血压史和脑卒中史的患者A/A基因型分别占51.4%和60.0%,高于无高血压史和无脑卒中史患者,差异均有统计学意义(P<0.05);A/A基因型的脑卒中患者24h平均收缩压、24h平均舒张压、24h平均脉压、24h动态脉压指数均高于基因型为A/G和G/G者,差异均有统计学意义(P<0.05)。结论脑卒中患者TGFBR2基因rs6785358基因型以A/A为主,且A/A基因型患者血压波动性较大。
Objective To explore the relationship between the TFGBR2 gene polymorphism and the indexes of ambulatory blood pressure in patients with stroke. Methods A total of 60 cases of patients diagnosed with stroke,including 32 cases of patients with cerebral hemorrhage（cerebral hemorrhage group） and 28 cases of patients with cerebral infarction（cerebral infarction group）, were selected in our hospital from June 2014 to June 2015. Another 60 cases of healthy individuals were allocated to the control group. The PCR-RFLP method was used to determine TGFBR2 rs6785358 gene polymorphism,and all patients were given ambulatory blood pressure monitoring. The relationship between the TFGBRZ gene polymorphism and the indexes of ambulatory blood pressure in patients with stroke were analysed. Results The A/A genotype accounted for 50.0% of rs6785358 gene in patients with cerebral hemorrhage and patients with cerebral infarction, which was higher than that in the control group, there was statistically significant difference（P〈0.05）. The ratio of G/G genotype（60.0%） in the control group was higher than that of patients with stroke,there was statistically significant difference（P〈0. 05）. The A/A genotype accounted for 51. 4% and 60. 0%of rs6785358 gene in patients with stroke who had hypertension history and those had stroke history, which was significantly higher than that in patients without hypertension history and stroke history,respectively. The 24 h MSBP,24 h MDBP,24 h PP and 24 h PPI in patients with cerebral stroke carrying A/A genotype of rs6785358 gene were higher than those in patients with cerebral stroke carrying A/G or G/G genotype of rs6785358 gene, there were statistically significant differences （P〈0.05）. Conclusion The A/A is the major genotype of TGFBR2 rs6785358,and patients with stroke carrying the A/A genotype have significant blood pressure fluctuations.
出处
《重庆医学》
CAS
北大核心
2016年第35期4983-4985,共3页
Chongqing medicine
关键词
转化生长因子Β
基因多态性
卒中
动态血压
trans
orming growth factor beta
gene polymorphism
stroke
ambulatory blood pressure
