摘要
目的探讨一氧化氮(Nitric oxide,NO)和转化生长因子-β1(Transforming growth factor-β1,TGF-β1)血浆水平与进展性脑卒中(progression stroke,PS)的关系。方法对发病24h内住院经头颅CT和/或MRI检查证实为大脑中动脉(MCA)供血区脑梗死的患者,以斯堪的那维亚卒中量表(SSS)在住院72h内评分较入院时下降2分以上者判定为PS的标准。诊断为PS患者51例。以入院时SSS评分相近的MCA供血区非PS患者为对照组(54例);在住院48h内空腹抽取静脉血进行NO、TGF-β1测定,并对双侧颈动脉作彩色多普勒检查。结果2组年龄、入院时评分SSS及合并症(高血压病、糖尿病、冠心病、高胆固醇血症史)无显著性差异(P>0.05)。PS组NO和TGF-β1水平显著低于对照组(P<0.01),PS组颈动脉内膜-中膜厚度(inti ma-media thickness,I MT)显著高于对照组(P<0.05)。结论NO和TGF-β1水平显著下降是PS发生发展的因素之一,脑梗死早期检测其血浆NO和TGF-β1水平有助于预测PS的发生,为临床的治疗决策和预后判断具有重要意义。
Objective To explore the relationship between plasma levels of nitric oxide（NO） and transforming growth factor-β1（TGF-β1） and progressing stroke（PS）.Methods Scandinavian Stroke Scale（SSS） was used to access patients with cerebral infarction of the middle cerebral artery（MCA） area confirmed by head CT and/or MRI examination admitted within 24 hours after onset.PS was defined as a decrease of ≥2 SSS points when assessed at baseline compared to 72 hours after admission.Fifty-one patients were diagnosed with PS,while non-PS patients（54 cases） with the similar SSS scores for MCA area were chosen as control group.Fasting venous blood samples were obtained for determination of serum NO and TGF-β1.Results There was no significant difference between the two groups in age,SSS score at admission and complications（hypertension,diabetes,Coronary heart diseases and hypercholesterolemia）（P〉0.05）.The levels of NO and TGF-β1 in PS were significantlly lower than those in control group（P〈0.01）.The intima-media thickness（IMT）in PS was significantlly thicker than that in control group（P〈0.01）.Conclusions A marked decrease of NO and TGF-β1 level is one factor for the occurrence and development of PS.These findings suggest that early detection of plasma levels of NO and TGF-β1 could help to predict PS,and this is of great significance in clinical decision-making process and prognostic assessment.
出处
《卒中与神经疾病》
2010年第1期16-19,共4页
Stroke and Nervous Diseases
基金
广东省卫生厅医学科研基金资助(A2007312)
关键词
进展性脑卒中
一氧化氮
转化生长因子-Β1
Progressing stroke（PS） Nitric oxide（NO） Transforming growth factor-β1（TGF-β1）
