摘要
目的探讨医院常见革兰阴性菌2009-2014年对喹诺酮类药物耐药性变迁趋势,指导临床喹诺酮类抗菌药物使用。方法对广西医院2009-2014年临床标本分离的常见革兰阴性菌对喹诺酮类药物耐药率变迁进行统计和分析,数据采用SPSS 18.0软件进行统计分析。结果医院7种常见革兰阴性菌中,以大肠埃希菌及不动杆菌属耐药率最高,连续6年大肠埃希菌对环丙沙星及左氧氟沙星耐药率均>60.0%,不动杆菌属对上述2种喹诺酮类药物耐药率均>58.9%。结论医院革兰阴性菌对环丙沙星及左氧氟沙星耐药形势严峻,以大肠埃希菌、不动杆菌属最为严重,临床医生经验用药应参考医院细菌耐药监测数据,最大限度发挥喹诺酮类药物的作用。
OBJECTIVE To explore the evolution of the resistance of common gram-negative bacteria in hospitals to quinolones from 2009 to 2014, so as to guide the clinical use of quinolone antibacterial agents. METHODS The evolution of the resistance of common gram-negative bacteria isolated from clinical specimens of a large top three hospital a in Guangxi province from 2009 to 2014 was discussed by statistics and analysis. The data were analyzed by SPSS 18.0. RESULTS Among seven common gram-negative bacteria in hospital, Escherichia coli and Acinetobacter showed the highest drug resistance rates： for six consecutive years, the drug resistance rates of E. coli to ciprofloxacin and levofloxacin were above 60 %, while those of Acinetobacter to ciprofloxacin and levofloxacin were above 58.9 %. CONCLUSION The situation of the resistance of gram-negative bacteria in hospital to ciprofloxacin and levofloxacin is grim, and E. coli and Acinetobacter face the most formidable challenge. Experience-directed medication of clinicians should refer to the bacterial resistance surveillance data of this hospital and maximize the effects of quinolone drugs.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第24期5521-5523,共3页
Chinese Journal of Nosocomiology
关键词
革兰阴性菌
耐药
喹诺酮
Gram-negative bacteria
Drug resistance
Quinolone
