摘要
目的调查3年来铜绿假单胞菌在下呼吸道感染中的检出情况及其对常用抗生素的耐药现状,了解下呼吸道感染铜绿假单胞菌的耐药性变迁趋势,为临床治疗和控制由铜绿假单胞菌引起的下呼吸道感染提供参考依据。方法统计2011年1月-2013年12月某三甲医院下呼吸道感染患者铜绿假单胞菌的检出及其对临床常用的20种抗生素的药敏情况,并对它们的耐药性及其变迁趋势进行分析。结果 3年来铜绿假单胞菌在下呼吸道感染中的检出率分别为9.5%、13.7%、15.2%,对头孢他啶、环丙沙星、哌拉西林/他唑巴坦、亚胺培南、左氧氟沙星、哌拉西林、头孢哌酮/舒巴坦、阿米卡星8种抗生素的敏感率差异有统计学意义(P<0.05),多重耐药的铜绿假单胞菌所占比例分别为61.1%、66.7%、74.5%,呈现明显逐年上升的趋势。结论铜绿假单胞菌是下呼吸道感染重要的病原菌,对常用抗生素的耐药率逐年上升并日趋严重,多重耐药的情况正在进一步恶化。
Objective To investigate the detection situation and antibiotic resistance of Psudomnas aeruginosa（ P. a） in lower respiratory tract infections in recent three years,as well as the resistant trend of Psudomnas aeruginosa,and provide a reference for the clincial treatment and prevention of lower respiratory tract infections caused by Psudomnas aeruginosa. Methods Collected the detection rates of Psudomnas aeruginosa from the patients with lower respiratory tract infections from January,2011 to December,2013 in a grade three hospital,calculated the drug resistance rates to 20 kinds antibiotics,and analyzed the resistance and its variance trend. Results The detection rates of Psudomnas aeruginosa were respectively 9. 5%,13. 7% and15. 2% in 2011,2012 and 2013. The resistance rates difference to eight antibiotics of ceftazidime,ciprofloxacin,piperacillin /tazobactam,imipenem,levofloxacin,piperacillin,cefoperazone / sulbactam,and amilacin was statistically significant（ P〈0. 05）. The proportion of Psudomnas aeruginosa with multi- drug resistance were 61. 1%,66. 7% and 74. 5%,showing obvious uplifted trend yearly. Conclusion Psudomnas aeruginosa was an important bacterium in lower respiratory tract infections and it＇s resistance to common used antibiotics rises year after year. Multi- drug resistance was more and more severe.
出处
《中国卫生检验杂志》
CAS
2015年第2期286-288,共3页
Chinese Journal of Health Laboratory Technology
关键词
铜绿假单胞菌
耐药性
下呼吸道
Psudomnas aeruginosa
Resistance
Lower respiratory tract
