摘要
目前微波热疗技术已成为肿瘤热疗中被广泛认可的一种方法,然而微波加热区域与肿瘤的匹配程度低导致对正常组织的损伤偏高,为了提高有效温度覆盖率从而采用序列温度匹配方法对有效温度区域与肿瘤进行分析。通过仿真计算得到微波天线形成的比吸收率分布图像,再经过计算模拟出温度场分布,然后以此温度分布覆盖肿瘤图像,调整辐射功率和辐射时长,确定在有效治疗前提下的最小有效温度场,分析有效温度覆盖率,从而得到在进行肿瘤加热的同时将正常组织损伤降到最低的热疗方案。最后通过体模实验验证了此方法的有效性。
Microwave hyperthermia has become a widely accepted method in tumor hyperthermia. However, the low matching degree between microwave heating region and tumor causes high damages to normal tissues. The effective temperature region and tumor are analyzed by using the sequence temperature matching method to improve the effective temperature coverage rate. The specific absorption rate （SAR） distribution image generated by microwave antenna was firstly obtained through simulation calculation, and the temperature field distribution was simulated by Utilizing the SAR distribution image. Tumor image was covered with the temperature field distribution. The power and irradiation duration were adjusted to determine the minimum effective temperature field under the premise of effective treatment, and to analyze the effective temperature coverage rate, obtaining the hyperthermia program which caused the minimal damage to normal tissues during the heating of tumor. Finally, the effectiveness of this method was verified by the phantom experiment.
出处
《中国医学物理学杂志》
CSCD
2016年第12期1257-1261,共5页
Chinese Journal of Medical Physics
基金
国家自然科学基金(61301073
61661044)
关键词
肿瘤
热疗
微波
序列温度匹配
微带天线
tumor
hyperthermia
microwave
sequence temperature matching
micro-strip antenna
