摘要
目的：回顾性分析多西他赛联合铂类化疗70例晚期肺腺癌与肺鳞癌患者的临床疗效及生存差异，为晚期非小细胞肺癌患者个体化治疗提供参考。方法：收集2013年3月～2015年12月皖南医学院弋矶山医院经病理确诊的35例肺腺癌及35例肺鳞癌患者，均接受静滴多西他赛75 mg／m^2（d1），联合静滴铂类75 mg／m^2（d1～3），21 d为1周期，共化疗4周期，评价两组患者临床疗效及毒副作用。结果：肺腺癌、鳞癌组患者的客观有效率（ ORR）分别为20．0％、28．6％，疾病控制率（ DCR）分别为74．3％、71．4％。肺腺癌组患者中位生存期为16．6个月，1年及2年生存率分别为25．7％（9／35）、2．9％（1／35），肺鳞癌组患者中位生存期为18．2个月，1年及2年生存率分别为17．1％（6／35）、5．7％（2／35）。两组毒副作用主要为骨髓抑制及消化道反应，少数为肝功能异常、皮疹。结论：肺腺癌及肺鳞癌的临床疗效确切，且相似，能够有效延长其一定的生存时间，毒副作用均可耐受。
Objective：To retrospectively analyze the clinical effects and differences in survival in 70 patients with advanced squamous carcinoma or adeno-carcinoma received chemotherapy with docetaxel plus platinum（ DP regimen） in order to supply evidence for tailored treatment of the non-small cell lung cancer.Methods：Thirty-five patients with advanced pulmonary adenocarcinoma and another 35 with advanced pulmonary squamous carcinoma,pathologi-cally confirmed in Yijishan Hospital of Wannan Medical College from March of 2013 to December of 2015,underwent intravenous docetaxel（ administered on day 1） plus platinum（given from day 1 to day 3） in dose of 75 mg/m^2 for 4 therapy circles（21 days as one circle）.Then the two groups were evaluated regarding the clinical effects and adverse response.Results：The objective response rate（ORR） was 20.0%and 28.6%,and disease control rate（DCR） was 74.3%and 71.4%,respectively for cases of advanced pulmonary adenocarcinoma and squamous carcinoma .Median survival as well as 1-and 2-year surviv-al was 16.6 months and 18.2 months,25.7%and 17.1%,and 2.9%and 5.7%for adenocarcinoma and squamous carcinoma cases,respectively.The toxic effects were generally associated with bone marrow arrest and digestive tract reaction ,and liver damage and skin rash occurred in a few of cases in the two groups of patients.Conclusion：Docetaxel plus platinum may lead to similar effects on the lung adenocarcinoma or squamous carcinoma as well as to pro-longed survival time.The side effects can be tolerated by such patients during chemotherapy.
出处
《皖南医学院学报》
CAS
2016年第6期565-567,共3页
Journal of Wannan Medical College
关键词
非小细胞肺癌
多西他赛
化疗
non-small cell lung cancer
docetaxel
chemotherapy
